Pharmacist involved education program in a multidisciplinary team for oral mucositis: Its impact in head-and-neck cancer patients

Autor: Yusuke Tanaka, Kouji Katsura, Akira Toyama, Kensuke Yoshida, Marie Soga, Kyongsun Pak, Ritsuo Takagi, Yasumitsu Kodama
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Physiology
Cancer Treatment
Pharmacists
Weight loss
Medicine and Health Sciences
Clinical endpoint
Medicine
Medical Personnel
Analgesics
Multidisciplinary
Morphine
Delivery of Health Care
Integrated
Diagnosis
Oral
Incidence
Drugs
Chemoradiotherapy
Middle Aged
Professions
Exact test
Oncology
Physiological Parameters
Head and Neck Neoplasms
Research Design
Female
medicine.symptom
Research Article
Adult
medicine.medical_specialty
Patients
Clinical Research Design
Science
Pain
Research and Analysis Methods
Signs and Symptoms
Statistical significance
Internal medicine
Weight Loss
Mucositis
Humans
Pain Management
Retrospective Studies
Patient Care Team
Pharmacology
Stomatitis
business.industry
Body Weight
Head and neck cancer
Biology and Life Sciences
Cancer
Retrospective cohort study
medicine.disease
Opioids
Health Care
People and Places
Population Groupings
Adverse Events
Clinical Medicine
business
Anesthesia
Local
Zdroj: PLoS ONE, Vol 16, Iss 11, p e0260026 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: Objectives This retrospective study examined how a pharmacist-involved education program in a multidisciplinary team (PEMT) for oral mucositis (OM) affected head-and-neck cancer (HNC) patients receiving concurrent chemoradiotherapy (CCRT). Materials and methods Total samples data of 53 patients during the stipulated timeframe were retrospectively collected from electronic medical records from February 2017 to January 2019. We compared the presence/absence of OM (OM: yes/no) between patients with and without PEMT (PEMT: yes/no) as the primary endpoint and OM severity as the secondary endpoint. The following information was surveyed: age, gender, weight loss, steroid or immunosuppressant use, hematological values (albumin, white blood cell count, blood platelets, and neutrophils), cancer grade, primary cancer site, type and use of mouthwash and moisturizer, opioid use (yes/no, days until the start of opioid use, and dose, switch to tape), and length of hospital day (LOD). The two groups were compared using Fisher’s exact test for qualitative data and the Mann-Whitney U test for quantitative data, and a significance level of p.05 was set. Results The group managed by PEMT had significantly lower weight loss and a significantly lower incidence of local anesthetic and opioid use and switch to tape compared with the group not managed by PEMT (p.05). The two groups showed no significant difference in OM (yes/no) or OM severity. The PEMT group had significantly shorter LOD at 57 (53–64) days compared with the non-PEMT group at 63.5 (57–68) days (p.05). Conclusions Our results showed that PEMT did not improve OM (yes/no) or OM severity in HNC patients undergoing CCRT. However, the PEMT group had a lower incidence of grades 3 and 4 OM than the non-PEMT group, although not significantly. In addition, PEMT contributed to oral pain relief and the lowering of the risk for OM by reduction in weight loss.
Databáze: OpenAIRE
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