Pharmacist involved education program in a multidisciplinary team for oral mucositis: Its impact in head-and-neck cancer patients
Autor: | Yusuke Tanaka, Kouji Katsura, Akira Toyama, Kensuke Yoshida, Marie Soga, Kyongsun Pak, Ritsuo Takagi, Yasumitsu Kodama |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
Physiology Cancer Treatment Pharmacists Weight loss Medicine and Health Sciences Clinical endpoint Medicine Medical Personnel Analgesics Multidisciplinary Morphine Delivery of Health Care Integrated Diagnosis Oral Incidence Drugs Chemoradiotherapy Middle Aged Professions Exact test Oncology Physiological Parameters Head and Neck Neoplasms Research Design Female medicine.symptom Research Article Adult medicine.medical_specialty Patients Clinical Research Design Science Pain Research and Analysis Methods Signs and Symptoms Statistical significance Internal medicine Weight Loss Mucositis Humans Pain Management Retrospective Studies Patient Care Team Pharmacology Stomatitis business.industry Body Weight Head and neck cancer Biology and Life Sciences Cancer Retrospective cohort study medicine.disease Opioids Health Care People and Places Population Groupings Adverse Events Clinical Medicine business Anesthesia Local |
Zdroj: | PLoS ONE, Vol 16, Iss 11, p e0260026 (2021) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Objectives This retrospective study examined how a pharmacist-involved education program in a multidisciplinary team (PEMT) for oral mucositis (OM) affected head-and-neck cancer (HNC) patients receiving concurrent chemoradiotherapy (CCRT). Materials and methods Total samples data of 53 patients during the stipulated timeframe were retrospectively collected from electronic medical records from February 2017 to January 2019. We compared the presence/absence of OM (OM: yes/no) between patients with and without PEMT (PEMT: yes/no) as the primary endpoint and OM severity as the secondary endpoint. The following information was surveyed: age, gender, weight loss, steroid or immunosuppressant use, hematological values (albumin, white blood cell count, blood platelets, and neutrophils), cancer grade, primary cancer site, type and use of mouthwash and moisturizer, opioid use (yes/no, days until the start of opioid use, and dose, switch to tape), and length of hospital day (LOD). The two groups were compared using Fisher’s exact test for qualitative data and the Mann-Whitney U test for quantitative data, and a significance level of p.05 was set. Results The group managed by PEMT had significantly lower weight loss and a significantly lower incidence of local anesthetic and opioid use and switch to tape compared with the group not managed by PEMT (p.05). The two groups showed no significant difference in OM (yes/no) or OM severity. The PEMT group had significantly shorter LOD at 57 (53–64) days compared with the non-PEMT group at 63.5 (57–68) days (p.05). Conclusions Our results showed that PEMT did not improve OM (yes/no) or OM severity in HNC patients undergoing CCRT. However, the PEMT group had a lower incidence of grades 3 and 4 OM than the non-PEMT group, although not significantly. In addition, PEMT contributed to oral pain relief and the lowering of the risk for OM by reduction in weight loss. |
Databáze: | OpenAIRE |
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