Effect of low intensity pulsed ultrasound on healing of an ulna defect filled with a bone graft substitute
| Autor: | William R. Walsh, Frank Vizesi, Neill M. Pounder, Andrew J. Langdown, Jason Auld, Warwick Bruce, Yan Yu, Paul Stephens |
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| Rok vydání: | 2007 |
| Předmět: |
Calcium Phosphates
medicine.medical_specialty Materials science Radiography Biomedical Engineering Biocompatible Materials Ulna Low-intensity pulsed ultrasound Bone and Bones Biomaterials Bone Density Surgical site medicine Animals Ultrasonics Bone Resorption Ultrasonography Bone mineral Bone Transplantation Models Statistical business.industry Significant difference Histology Immunohistochemistry Resorption Surgery medicine.anatomical_structure Bone Substitutes Bone Remodeling Rabbits business |
| Zdroj: | Journal of biomedical materials research. Part B, Applied biomaterials. 86(1) |
| ISSN: | 1552-4981 |
| Popis: | A 1.5 cm unilateral rabbit ulna defect model was performed in 18 adult NZ white rabbits. The defects were filled with a β-tricalcium phosphate bone graft substitute (JAX TCP). The surgical site in half the animals was treated daily with 20 min of low intensity pulsed ultrasound (LIPUS). Animals were sacrificed at 4 weeks (n = 3 per group) or 12 weeks (n = 6 per group) following surgery for radiographic and histologic endpoints. Radiography revealed some resorption of the JAX TCP by 12 weeks in the control and LIPUS treated groups. LIPUS treatment did not accelerate this resorption. Some new bone formation was noted in the control groups at the defect margins while little bone formed in the center of the defect at 4 and 12 weeks. In contrast, radiographs revealed more new bone at 4 and 12 weeks in the LIPUS treated animals throughout the section. Bone mineral density (DEXA) revealed a statistically significant difference at 4 weeks with LIPUS while no differences were found at 12 weeks. Histology of the LIPUS treated sections demonstrated new woven bone formation on and between the JAX TCP bone graft substitute particles across the defect. VEGF expression was increased with LIPUS treatment at 4 weeks and remained elevated at 12 weeks compared with controls. CBFA-1 expression levels were elevated with LIPUS treatment at both time points. LIPUS treatment increased bone formation in ulna defect healing with a β-tricalcium phosphate bone graft substitute. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008 |
| Databáze: | OpenAIRE |
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