Nitric oxide synthase inhibition reduces wakefulness
| Autor: | R. de Vries, M.R. Dzoljic |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
inorganic chemicals
Male medicine.medical_specialty Arginine Rapid eye movement sleep Sleep REM Nitric Oxide Nitric oxide Cellular and Molecular Neuroscience chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar Wakefulness Slow-wave sleep Pharmacology omega-N-Methylarginine biology ATP synthase Electroencephalography Rats Nitric oxide synthase Endocrinology chemistry cardiovascular system Excitatory postsynaptic potential biology.protein Amino Acid Oxidoreductases Nitric Oxide Synthase Arousal Sleep |
| Zdroj: | Neuropharmacology. 33(11) |
| ISSN: | 0028-3908 |
| Popis: | The effect of N G - monomethyl- l -arginine ( l -NMMA), an inhibitor of nitric oxide (NO) synthase and l -arginine, a precursor of NO, was examined on the sleep-waking pattern in rats. l -NMMA (3.75–15 mg/kg, i.p.) reduced wakefulness with a corresponding increase of slow wave sleep and rapid eye movement sleep. The effect of l -NMMA on vigilance was limited to the first hour following drug administration. The effect of l -NMMA was abolished by intracerebroventricular administration of l -arginine (600 μg). This indicates that the inhibitory effect of l -NMMA on wakefulness is mediated by decreased NO synthesis and that central NO exerts an excitatory role in vigilance. It further implicates that factors facilitating a release and/or synthesis of NO might lead to increased wakefulness and sleep disturbances. |
| Databáze: | OpenAIRE |
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