The multifaceted role of glial cells in amyotrophic lateral sclerosis
| Autor: | Chiara F. Valori, Liliana Brambilla, Daniela Rossi, Francesca Martorana |
|---|---|
| Přispěvatelé: | Valori, C, Brambilla, L, Martorana, F, Rossi, D |
| Rok vydání: | 2013 |
| Předmět: |
Cell Cycle Proteins
metabolism [Microglia] 0302 clinical medicine Superoxide Dismutase-1 Transcription Factor TFIIIA genetics [Superoxide Dismutase] cytology [Microglia] Amyotrophic lateral sclerosis cytology [Astrocytes] metabolism [RNA-Binding Protein FUS] 0303 health sciences Microglia metabolism [Astrocytes] Neurodegeneration SOD1 protein human DNA-Binding Proteins Oligodendroglia medicine.anatomical_structure Transgenic animal etiology [Amyotrophic Lateral Sclerosis] Molecular Medicine metabolism [DNA-Binding Proteins] Astrocyte Human DNA-Binding Protein metabolism [Superoxide Dismutase] genetics [DNA-Binding Proteins] Biology OPTN protein human metabolism [Oligodendroglia] 03 medical and health sciences Cellular and Molecular Neuroscience genetics [Transcription Factor TFIIIA] Glia medicine Animals Humans ddc:610 pathology [Amyotrophic Lateral Sclerosis] Molecular Biology cytology [Oligodendroglia] Amyotrophic lateral sclerosi metabolism [Transcription Factor TFIIIA] 030304 developmental biology Pharmacology Animal Superoxide Dismutase metabolism [Amyotrophic Lateral Sclerosis] Amyotrophic Lateral Sclerosis Membrane Transport Proteins Cell Biology Motor neuron medicine.disease Molecular medicine Disease Models Animal nervous system Astrocytes Immunology RNA-Binding Protein FUS Neuroscience genetics [RNA-Binding Protein FUS] 030217 neurology & neurosurgery |
| Zdroj: | Cellular and molecular life sciences 71(2), 287-297 (2013). doi:10.1007/s00018-013-1429-7 Cellular and molecular life sciences : CMLS |
| ISSN: | 1420-9071 |
| DOI: | 10.1007/s00018-013-1429-7 |
| Popis: | Despite indisputable progress in the molecular and genetic aspects of amyotrophic lateral sclerosis (ALS), a mechanistic comprehension of the neurodegenerative processes typical of this disorder is still missing and no effective cures to halt the progression of this pathology have yet been developed. Therefore, it seems that a substantial improvement of the outcome of ALS treatments may depend on a better understanding of the molecular mechanisms underlying neuronal pathology and survival as well as on the establishment of novel etiological therapeutic strategies. Noteworthy, a convergence of recent data from multiple studies suggests that, in cellular and animal models of ALS, a complex pathological interplay subsists between motor neurons and their non-neuronal neighbours, particularly glial cells. These observations not only have drawn attention to the physiopathological changes glial cells undergo during ALS progression, but they have moved the focus of the investigations from intrinsic defects and weakening of motor neurons to glia-neuron interactions. In this review, we summarize the growing body of evidence supporting the concept that different glial populations are critically involved in the dreadful chain of events leading to motor neuron sufferance and death in various forms of ALS. The outlined observations strongly suggest that glial cells can be the targets for novel therapeutic interventions in ALS. © 2013 Springer Basel |
| Databáze: | OpenAIRE |
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