Angioedema Due to Acquired Deficiency of C1-Inhibitor: A Cohort Study in Spain and a Comparison With Other Series
| Autor: | F.J. Muñoz-Bellido, M. Castro, B. Sáenz de San Pedro, C. Díaz, E. Escudero, Maria L. Baeza, Anna Sala-Cunill, Teresa Caballero, A. Prieto-García, M.G. García, R. Núñez, T González-Quevedo, S. Varela, E. Laffond, Mar Guilarte, R. Lleonart, N. Prior |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Delayed Diagnosis Lymphoproliferative disorders Asymptomatic C1-inhibitor Autoimmune Diseases Autoimmune thyroiditis Cohort Studies Acquired immunodeficiency syndrome (AIDS) medicine Immunology and Allergy Humans Lupus Erythematosus Systemic Angioedema biology business.industry Angioedemas Hereditary Thyroiditis Autoimmune Retrospective cohort study bacterial infections and mycoses medicine.disease Spain biology.protein Female medicine.symptom business Complement C1 Inhibitor Protein Cohort study |
| Zdroj: | The journal of allergy and clinical immunology. In practice. 10(4) |
| ISSN: | 2213-2201 |
| Popis: | [Background] Data on acquired angioedema due to C1-inhibitor deficiency (C1-INH-AAE) from 4 European countries (France, Italy, Germany, and Hungary) were recently published. [Objective] To report data from a group of 50 patients with acquired C1-INH deficiency from Spain, of whom 46 had angioedema, and compare them with other European series. [Methods] We performed a retrospective observational study of 46 patients with C1-INH-AAE and 4 asymptomatic patients. Clinical and biological characteristics and associated diseases were assessed and compared with other European series. [Results] Women accounted for 73.9% of cases. The prevalence of C1-INH-AAE related to hereditary forms was 1/10.1. Overall, 8.7% patients were aged [Conclusions] This study emphasizes the possibility of C1-INH-AAE in patients younger than 40 and in autoimmune diseases other than systemic lupus erythematosus such as autoimmune thyroiditis. |
| Databáze: | OpenAIRE |
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