Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding
| Autor: | Boris D. Heifets, Sophie Neuner, Gordon Sun, Hemmings Wu, Daniel J. Christoffel, Jessica J. Walsh, Casey H. Halpern, Paul Hoerbelt, Vinod K Ravikumar, Robert C. Malenka |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Patch-Clamp Techniques Science Transgene Thalamus Midline Thalamic Nuclei Prefrontal Cortex General Physics and Astronomy Mice Transgenic Nucleus accumbens Optogenetics Biology Nucleus Accumbens Article General Biochemistry Genetics and Molecular Biology Stereotaxic Techniques Eating Mice 03 medical and health sciences 0302 clinical medicine Reward Neural Pathways medicine Animals Obesity Prefrontal cortex Neurons Motivation Microscopy Confocal Neuronal Plasticity Multidisciplinary Feeding Behavior General Chemistry Animal Feed Dietary Fats 030104 developmental biology medicine.anatomical_structure Models Animal Stereotaxic technique Vesicular Glutamate Transport Protein 2 Excitatory postsynaptic potential Nucleus Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021) Nature Communications |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-021-22430-7 |
| Popis: | Hedonic feeding is driven by the “pleasure” derived from consuming palatable food and occurs in the absence of metabolic need. It plays a critical role in the excessive feeding that underlies obesity. Compared to other pathological motivated behaviors, little is known about the neural circuit mechanisms mediating excessive hedonic feeding. Here, we show that modulation of prefrontal cortex (PFC) and anterior paraventricular thalamus (aPVT) excitatory inputs to the nucleus accumbens (NAc), a key node of reward circuitry, has opposing effects on high fat intake in mice. Prolonged high fat intake leads to input- and cell type-specific changes in synaptic strength. Modifying synaptic strength via plasticity protocols, either in an input-specific optogenetic or non-specific electrical manner, causes sustained changes in high fat intake. These results demonstrate that input-specific NAc circuit adaptations occur with repeated exposure to a potent natural reward and suggest that neuromodulatory interventions may be therapeutically useful for individuals with pathologic hedonic feeding. Hedonic feeding occurs in the absence of metabolic need and plays a critical role in the excessive feeding that underlies obesity. The authors show that optogenetic manipulation of NAc inputs from the prefrontal cortex versus inputs from the anterior paraventricular nucleus of the thalamus has opposite effects on high fat intake. |
| Databáze: | OpenAIRE |
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