CHYLOTHORAX IN PARACOCCIDIOIDOMYCOSIS

Autor: Tarquino Erastides Gavilanes Sánchez, Wagner Diniz de Paula, Alfredo Nicodemos Cruz Santana, Victor Oliveira Alves, Flávia Fonseca Fernandes
Rok vydání: 2016
Předmět:
Zdroj: Revista do Instituto de Medicina Tropical de São Paulo
Repositório Institucional da UnB
Universidade de Brasília (UnB)
instacron:UNB
Revista do Instituto de Medicina Tropical de São Paulo, Vol 58, Iss 0 (2016)
ISSN: 0036-4665
DOI: 10.1590/s1678-9946201658057
Popis: SUMMARY A previously healthy, 52-year-old woman presented with a nine months history of low fever and weight loss (> 30 kg). Physical examination disclosed generalized lymphadenopathy, skin lesions, abdominal distension, mild tachypnea and a left breast mass. Laboratory tests showed anemia; (prerenal) kidney injury, low serum albumin level; and negative serology for HIV and viral hepatitis. Computed tomography (neck/chest/abdomen) showed generalized lymph node enlargement, splenomegaly, pleural effusion and ascites. We performed thoracocentesis and paracentesis, and the findings were consistent with chylothorax and chylous ascites (with no neoplastic cells). Biopsies of the breast mass, skin and lymph nodes were performed and all of them showed large round yeast cells with multiple narrow-based budding daughter cells, characteristic of Paracoccidioides brasiliensis. Consequently, paracoccidioidomycosis was diagnosed, and liposomal amphotericin B was prescribed, as well as a high protein and low fat diet (supplemented with medium chain triglycerides). Even so, her clinical status worsened, requiring renal replacement therapy. She evolved with pneumonia, septic shock and respiratory failure and subsequently died. To our knowledge, this is the first description of a case with chylothorax and breast mass due to paracoccidioidomycosis. Additionally, we discuss: 1- the importance of the inclusion of this mycosis in the differential diagnosis of chylothorax and breast mass (breast cancer), especially in endemic areas; and 2- the possible mechanism involved in the development of chylous effusions.
Databáze: OpenAIRE
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