Carotid intima-media thickness and flow-mediated dilation in obese children with non-alcoholic fatty liver disease
| Autor: | Tugrul Donmez, İlker Tolga Özgen, Sinem Aydın, Emel Torun, Selim Gökçe, Yaşar Cesur |
|---|---|
| Přispěvatelé: | AYDIN, SİNEM |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Carotid Intima-Media Thickness Severity of Illness Index Gastroenterology Body Mass Index Insulin resistance Non-alcoholic Fatty Liver Disease Predictive Value of Tests Risk Factors Internal medicine medicine Humans Obesity Child the official journal of Turkish Society of Gastroenterology ss.92-8 2014 [Torun E. Aydin S. Gokce S. Ozgen I. T. Donmez T. Cesur Y. -Carotid intima-media thickness and flow-mediated dilation in obese children with non-alcoholic fatty liver disease.- The Turkish journal of gastroenterology] Triglycerides medicine.diagnostic_test business.industry Cholesterol HDL Fatty liver Alanine Transaminase Cholesterol LDL Atherosclerosis medicine.disease digestive system diseases Vasodilation Endocrinology Intima-media thickness Case-Control Studies Homeostatic model assessment Female Median body Insulin Resistance Steatosis Lipid profile business Body mass index |
| Zdroj: | The Turkish Journal of Gastroenterology. 25:92-98 |
| ISSN: | 2148-5607 1300-4948 |
| DOI: | 10.5152/tjg.2014.5552 |
| Popis: | Background/Aims: This study aimed to understand the role of non-alcoholic fatty liver disease (NAFLD) in increasing the risk of atherosclerosis in obese pediatric patients. Materials and Methods: The study included 109 obese children (age, 9-15 years) and a control group comprising 44 healthy age- and gender-matched children with normal weight. NAFLD was diagnosed using conventional ultrasound (US) examination. Both right carotid intima-media thickness (CIMT) and flow-mediated dilation (FMD) were assessed in addition to anthropometric measures and serum biochemical parameters, including lipid profile and fasting glucose and insulin levels. Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated as a measure of insulin resistance. Results: Mean age and gender distributions were similar in the obese children and control group (p=0.168 and p=0.705, respectively). Median body mass index standard deviation scores of obese children with grade II-III NAFLD were significantly higher than those of obese children without hepatosteatosis (p |
| Databáze: | OpenAIRE |
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