Multiparity upregulates placental plasminogen and urokinase-type plasminogen activator
| Autor: | María Rocío Rial Hawila, María Eugenia Cortina, S. Miranda, Silvana Litwin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
placenta Placenta Blotting Western Immunology Matrix metalloproteinase Biology Andrology Ciencias Biológicas Mice 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Pregnancy medicine Animals Immunology and Allergy mouse Urokinase Fetus 030219 obstetrics & reproductive medicine Decidua Obstetrics and Gynecology Trophoblast Plasminogen Immunohistochemistry Urokinase-Type Plasminogen Activator Placentation Trophoblasts Up-Regulation Parity uPA/PLAU 030104 developmental biology medicine.anatomical_structure Reproductive Medicine parity Models Animal embryonic structures plasminogen Female Biología Reproductiva Plasminogen activator CIENCIAS NATURALES Y EXACTAS medicine.drug |
| DOI: | 10.1111/aji.12633 |
| Popis: | Problem: Multiparity increased the number of trophoblast cells in decidua of both low and high fetal loss mouse models. However, they differ in fetal survival rate and maternal thymocyte subpopulations, suggesting that trophoblast invasiveness is not equivalent. Our aim was to explore the involved mechanism. Method of study: We studied placentae from primiparous and multiparous females of low and high fetal loss models. We investigated invasiveness in vitro, expression of plasminogen, and its activators: tissue type (tPA)‐urokinase type (uPA), and activity and expression of matrix metalloproteinases (MMP)‐2 and MMP‐9. Results: Placental invasiveness is upregulated by multiparity, but lesser in the high fetal loss model. Multiparous animals showed elevated expression of plasminogen and uPA. However, the high fetal loss combination showed higher expression of a short and less active fragment of uPA (LMW‐uPA). MMP‐2, MMP‐9, and tPA were unaffected. Conclusion: uPA would participate in the increased multiparity‐associated placental invasiveness. Fil: Cortina, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina Fil: Litwin, Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina Fil: Rial Hawila, María Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina Fil: Miranda, Silvia Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina |
| Databáze: | OpenAIRE |
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