| Autor: |
Asghar, S, Monkley, S, Smith, DJF, Hewitt, RJ, Grime, K, Murray, LA, Overed-Sayer, CL, Molyneaux, PL |
| Rok vydání: |
2023 |
| Zdroj: |
Respiratory Research. 24 |
| ISSN: |
1465-993X |
| Popis: |
Background Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that affects 3 million people worldwide. Senescence and small extracellular vesicles (sEVs) have been implicated in the pathogenesis of IPF, although how sEVs promote disease remains unclear. Here, we profile sEVs from bronchial epithelial cells and determine small RNA (smRNA) content. Methods Conditioned media was collected and sEVs were isolated from normal human bronchial epithelial cells (NHBEs) and IPF-diseased human bronchial epithelial cells (DHBEs). Results Increased sEV release from DHBEs compared to NHBEs (n = 4; p Conclusions This data demonstrates that DHBE-derived sEVs transfer senescence to neighbouring healthy cells, promoting the disease state in IPF. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink