Follistatin-like 1 mitigates intermittent hypoxia-induced melanoma lung metastasis in mice

Autor: Chao Qi, Jie Cao, Xingzu Liu, Qianqian Chen, Maoli Liang, Zhongjie Chen, Jing Feng, Baoyuan Chen, Wen Ning, Lian Li
Rok vydání: 2022
Předmět:
Zdroj: Sleep and Breathing. 27:1165-1173
ISSN: 1522-1709
1520-9512
DOI: 10.1007/s11325-022-02680-5
Popis: Intermittent hypoxia (IH) mimicking obstructive sleep apnea (OSA) has been confirmed to induce tumor lung metastasis via oxidative stress and inflammation responses. Follistatin-like 1 (Fstl1), as a matricellular protein, plays critical roles in inflammatory diseases and cancer. This study aimed to investigate the effect and mechanism of Fstl1 on OSA-IH-induced tumor lung metastasis.Fstl1Fstl1 levels are decreased in lung tissues from OSA-IH injured mice inoculated with melanoma cells. Fstl1-deficient mice were highly susceptible to the OSA-IH model of melanoma lung metastasis, as assessed by increased number and area of lung metastatic colonies, and by the elevated levels of HIF-1α, Vegf, N-cadherin, and E-cadherin. Lung melanoma tissue in Fstl1These results suggest that Fstl1 may protect against OSA-IH-induced tumor lung metastasis through oxidative stress and inflammatory responses. Fstl1 may serve as a promising target for OSA-related cancer.
Databáze: OpenAIRE
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