Anaphylatoxin and terminal complement complexes in red cell salvage
| Autor: | A. Bengtsson, B. Lisander |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Anaphylatoxins
Complement C5a chemical and pharmacologic phenomena Cell Separation Complement Membrane Attack Complex Pharmacology Blood Transfusion Autologous Terminal complement complex Humans Medicine Anaphylatoxin Elective surgery Aged Aged 80 and over Red Cell business.industry General Medicine Plasma levels Middle Aged Complement (complexity) Complement system Orthopedics Anesthesiology and Pain Medicine Immunology Complement C3a Female Erythrocyte Transfusion business Autotransfusion |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 34:339-341 |
| ISSN: | 1399-6576 0001-5172 |
| DOI: | 10.1111/j.1399-6576.1990.tb03098.x |
| Popis: | Thirteen patients undergoing elective orthopedic surgery were studied regarding anaphylatoxin (C3a and C5a) and terminal complement complex (TCC) formation in association with red cell salvage. The auto-transfusion equipment gave a centrifuged and washed erythrocyte fraction. The concentrations of C5a and TCC were not increased but elevated C3a levels were found in the suspension. After infusion of the erythrocyte fraction to the patient, no signs of systemic complement activation were observed. Thus, plasma levels of C3a, C5a and TCC were within the normal range in all the patients before and after autotransfusion. This study indicates that the complement system is activated in the cellsaver equipment. The washing procedure, however, seems to eliminate most of the anaphylatoxins and terminal complement complexes. No extensive systemic activation of complement seems to occur in association with autotransfusion to patients undergoing elective surgery. |
| Databáze: | OpenAIRE |
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