Protective Effects of Dexrazoxane against Doxorubicin-Induced Cardiotoxicity: A Metabolomic Study
| Autor: | Huo Yan, Wan Lili, Li Jie, Yang Quan-Jun, Gan Run, Guo Cheng, Lu Jin, Han Yong-Long, Yang Gen-jin, Huang Jin-Lu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Cancer Treatment Carnosine lcsh:Medicine Pharmacology Biochemistry chemistry.chemical_compound Mice 0302 clinical medicine Glucose Metabolism Drug Metabolism Metabolites Medicine and Health Sciences polycyclic compounds lcsh:Science Cardioprotection Multidisciplinary Antibiotics Antineoplastic Neurochemistry Animal Models Neurotransmitters Glutathione Oncology Experimental Organism Systems 030220 oncology & carcinogenesis Metabolome Carbohydrate Metabolism Glutamate Oxidation-Reduction medicine.drug Research Article Cardiotonic Agents Heart Diseases Mouse Models Research and Analysis Methods 03 medical and health sciences Model Organisms medicine Metabolomics Animals Doxorubicin Pharmacokinetics Dexrazoxane Nuclear Magnetic Resonance Biomolecular Cardiotoxicity Methionine lcsh:R Biology and Life Sciences Lipid Metabolism 030104 developmental biology Metabolism Glucose chemistry lcsh:Q Peptides Drug metabolism Biomarkers Neuroscience |
| Zdroj: | PLoS ONE, Vol 12, Iss 1, p e0169567 (2017) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Cardioprotection of dexrazoxane (DZR) against doxorubicin (DOX)-induced cardiotoxicity is contentious and the indicator is controversial. A pairwise comparative metabolomics approach was used to delineate the potential metabolic processes in the present study. Ninety-six BALB/c mice were randomly divided into two supergroups: tumor and control groups. Each supergroup was divided into control, DOX, DZR, and DOX plus DZR treatment groups. DOX treatment resulted in a steady increase in 5-hydroxylysine, 2-hydroxybutyrate, 2-oxoglutarate, 3-hydroxybutyrate, and decrease in glucose, glutamate, cysteine, acetone, methionine, asparate, isoleucine, and glycylproline.DZR treatment led to increase in lactate, 3-hydroxybutyrate, glutamate, alanine, and decrease in glucose, trimethylamine N-oxide and carnosine levels. These metabolites represent potential biomarkers for early prediction of cardiotoxicity of DOX and the cardioprotective evaluation of DZR. |
| Databáze: | OpenAIRE |
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