National Institute of Mental Health Collaborative Multimodal Treatment Study of Children with ADHD (the MTA). Design challenges and choices
| Autor: | Jeffrey H. Newcorn, Dennis P. Cantwell, L. Greenhill, Karen C. Wells, John S. March, B Hoza, E. Schiller, P. S. Jensen, Hb Abikoff, Lily Hechtman, C.K. Conners, We Pelham, John E. Richters, Gr Elliott, James M. Swanson, D Vereen, Joanne B. Severe, Helena C. Kraemer, Stephen P. Hinshaw, L. E. Arnold |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Imipramine Dextroamphetamine Decision Making MEDLINE Pemoline law.invention Arts and Humanities (miscellaneous) Randomized controlled trial Clinical Protocols law Behavior Therapy medicine Attention deficit hyperactivity disorder Humans Psychiatry Child Health policy National Institute of Mental Health (U.S.) Health Policy Patient Selection Health services research medicine.disease Mental health Combined Modality Therapy United States Clinical trial Psychiatry and Mental health Attention Deficit Disorder with Hyperactivity Research Design Methylphenidate Female Health Services Research Psychology Psychosocial |
| Zdroj: | Archives of general psychiatry. 54(9) |
| ISSN: | 0003-990X |
| Popis: | The Collaborative Multimodal Treatment Study of Children With Attention Deficit Hyperactivity Disorder (ADHD), the MTA, is the first child multisite cooperative agreement treatment study of children conducted by the National Institute of Mental Health, Rockville, Md. It examines the long-term effectiveness of medication vs behavioral treatment vs both for treatment of ADHD and compares state-of-the-art treatment with routine community care. In a parallel-groups design, 576 children (age, 7-9 years) with ADHD (96 at each site) are thoroughly assessed and randomized to 4 conditions: (1) medication alone, (2) psychosocial treatment alone, (3) the combination of both, (4) or community comparison. The first 3 groups are treated for 14 months and all are reassessed periodically for 24 months. Designers met the following challenges: framing clinically relevant primary questions; defining the target population; choice, intensity, and integration and combination of treatments for fair comparisons; combining scientific controls and standardization with clinical flexibility; and implementing a controlled clinical trial in a nonclinical setting (school) controlled by others. Innovative solutions included extensive decision algorithms and manualized adaptations of treatments to specific needs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|