Evaluating the prophylactic potential of zafirlukast against the toxic effects of acetic acid on the rat colon
| Autor: | Hanan H Hager, Azza A El-Medany, Afaf A. Mahgoub, Ali A. Mustafa, Doryia M El-Sabah |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Indoles Leukotriene D4 Colon Phenylcarbamates Pharmacology Toxicology Tosyl Compounds chemistry.chemical_compound Gum acacia Malondialdehyde medicine Animals Rats Wistar Zafirlukast Coloring Agents Acetic Acid Peroxidase Sulfonamides Leukotriene E4 biology Leukotriene C4 Leukotriene receptor General Medicine Catalase Colitis biology.organism_classification Glutathione Rats chemistry Myeloperoxidase Immunology biology.protein Leukotriene Antagonists medicine.drug |
| Zdroj: | Toxicology Letters. 145:79-87 |
| ISSN: | 0378-4274 |
| DOI: | 10.1016/s0378-4274(03)00269-8 |
| Popis: | The present work was conducted to assess the possible protective effects of zafirlukast against the toxic damage induced by acetic acid in rat colon. Zafirlukast is a potent and selective cysteinyl leukotriene receptor antagonist which is used mainly in the prophylaxis of bronchial asthma. Two doses of zafirlukast were used (40 and 80 mg/kg) dissolved in gum acacia and given either orally or rectally (0.5 ml/kg). Several parameters including, macroscopic score, histopathological and biochemical such as malondialdehyde (MDA), myeloperoxidase (MPO), catalase and reduced glutathione (GSH) levels were measured using standard assay procedures. The study showed that pretreatment with zafirlukast in a dose of 80 mg/kg orally produced a significant decrease in tissue malondialdehyde, myeloperoxidase, and an increase in both reduced glutathione and catalase levels, while there was no significant changes with the rectal route. The 40 mg/kg dose had no significant protective effects when given either orally or rectally. The available data indicate that the inhibition of leukotriene synthesis or action may have a role in inflammatory bowel disease (IBD) as they are considered as important mediators in this condition. |
| Databáze: | OpenAIRE |
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