Removal of immunoglobulins by a protein A versus an antihuman immunoglobulin G-based system: evaluation of 602 sessions of extracorporeal immunoadsorption
| Autor: | Eva‐Maria Kinze, Waltraud Müller, Wolfgang Ramlow, Michael Tiess, Goran Matic, Doris Hofmann, Gabi Hebestreit, Roland E. Winkler, Martin Keysser, Ann Michelsen, Jana‐Maria Schneidewind |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_treatment
Biomedical Engineering Medicine (miscellaneous) Bioengineering Blood volume Immunoglobulin G Biomaterials Hemoglobins Renal Dialysis medicine Humans Immunoadsorption Staphylococcal Protein A Immunosorbent Techniques Serum Albumin Hemodilution Blood Volume biology Plasma Exchange Chemistry General Medicine Antibodies Anti-Idiotypic Immunoglobulin A Immunoglobulin M Polyclonal antibodies Immunology biology.protein Blood Component Removal Plasmapheresis Hemoglobin Antibody Protein A Immunosorbents |
| Zdroj: | Artificial organs. 24(2) |
| ISSN: | 0160-564X |
| Popis: | Elimination of IgG can be achieved by extracorporeal immunoadsorption (IA) based on specific binding to either staphylococcal protein A (Excorim) or sheep polyclonal antibodies directed against human IgG (Therasorb). In 602 analyzed sessions of IA, elimination of IgG was 60% through 80% depending on the treated plasma volume, with no significant difference between the mentioned systems. However, the decrease of IgM and IgA was approximately 50% in the anti-IgG compared to 20-40% in the protein A system. Plasma albumin concentration decreased by 20% in the anti-IgG system compared to 15% in the protein A system, and hemoglobin values increased by 2% in the anti-IgG system and decreased by 6% in the protein A system. In conclusion, a clinical relevance for these findings cannot be ruled out, and the individual choice might depend on the clinical situation and laboratory findings. |
| Databáze: | OpenAIRE |
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