Severe sepsis caused by Parvimonas micra identified using 16S ribosomal RNA gene sequencing following patient death
| Autor: | Masaaki Takemoto, Tomoya Asaka, Manami Miyazaki, Takaaki Nakano |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Spondylodiscitis medicine.medical_specialty Pleural effusion 030106 microbiology Anaerobic infection Infectious and parasitic diseases RC109-216 Article law.invention Sepsis 03 medical and health sciences 0302 clinical medicine law Parvimonas micra medicine Back pain 030212 general & internal medicine Abscess business.industry medicine.disease Intensive care unit Iliopsoas abscess Surgery Infectious Diseases medicine.symptom Gas gangrene business |
| Zdroj: | IDCases, Vol 19, Iss, Pp-(2020) IDCases |
| ISSN: | 2214-2509 |
| Popis: | Highlights • Though Parvimonas micra is not generally regarded as virulent, it may cause fulminant infection in people with weak immune system. • The diagnosis of P. micra infection is sometimes missed because of its slow growth during culturing. Molecular methods may be helpful for identification. • Our patient died due to disseminated infection. The organism was later identified as P. micra using 16S ribosomal RNA sequencing. An 83-year-old man visited an orthopedic hospital for his lower back pain. A compression fracture was noted in his second lumbar vertebra. He had taken pain medication for approximately five weeks, but the pain had worsened and he was unable to walk by himself. He was transferred to our hospital and diagnosed with lumbar spondylodiscitis, an iliopsoas abscess, gas gangrene of his left lower limb, and left massive pleural effusion. He was admitted to the intensive care unit. We drained the abscess and pleural effusion, provided continuous hemodiafiltration under ventilator control, and administered intravenous antibiotics. However, he died from sepsis and multiple organ failure three days following admission. Several days after his death, gram-positive cocci were identified in blood culture, pus from the abscess, and pleural exudate; although the causative organism could not be identified. Two weeks subsequent to his death, 16S ribosomal RNA gene sequencing identified Parvimonas micra in specimens taken from his body. |
| Databáze: | OpenAIRE |
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