Cytogenetic Confirmation of a Gastrointestinal Stromal Tumor and Ewing Sarcoma/Primitive Neuroectodermal Tumor in a Single Patient
| Autor: | Koh Furuta, Hirokazu Chuman, Tadashi Hasegawa, Shinji Sakurai, Yoshisuke Ikezawa, Umio Yamaguchi, Ukihide Tateishi, Shunsuke Kondo |
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| Rok vydání: | 2005 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Receptor Platelet-Derived Growth Factor alpha Gastrointestinal Stromal Tumors CD34 Antigens CD34 Sarcoma Ewing In situ hybridization Polymerase Chain Reaction Neoplasms Multiple Primary Stomach Neoplasms medicine Humans Neuroectodermal Tumors Primitive Point Mutation Radiology Nuclear Medicine and imaging Retroperitoneal Neoplasms Stromal tumor In Situ Hybridization Fluorescence Aged GiST medicine.diagnostic_test business.industry General Medicine medicine.disease Proto-Oncogene Proteins c-kit Oncology Primitive neuroectodermal tumor Cytogenetic Analysis Immunohistochemistry Female Sarcoma RNA-Binding Protein EWS business Fluorescence in situ hybridization |
| Zdroj: | Japanese Journal of Clinical Oncology. 35:753-756 |
| ISSN: | 1465-3621 0368-2811 |
| Popis: | We report a rare case in which two tumor entities, a gastrointestinal stromal tumor (GIST) and Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET), with distinct cytogenetic features occurred in a single patient. The patient was a 72-year-old woman. The first tumor was a submucosal gastric tumor and was diagnosed as a low-risk group GIST based on morphological characteristics and the results of an immunohistochemical analysis for c-kit and CD34. Further cytogenetic analysis revealed that this tumor had a point mutation (D842V substitution) in exon 18 of the platelet-derived growth factor receptor alpha gene. The second tumor was found more than 4 years after the appearance of the first tumor. ES/PNET was highly suspected both morphologically and immunohistochemically, and the diagnosis was confirmed by the detection of an EWS rearrangement using a fluorescence in situ hybridization technique. Although the cytogenetic correlations of these two tumors are unclear, accurate histologic recognition is of clinical importance because the treatments for these two tumors differ. |
| Databáze: | OpenAIRE |
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