Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition
| Autor: | Gabriele Niedermann, Jaroslaw Maciaczyk, Marco Prinz, Tomasz Bogiel, Soroush Doostkam, Charles G. Eberhart, Ulf Dietrich Kahlert, Donata Maciaczyk, Brent A. Orr, Jörg Schubert, Guido Nikkhah, Thomas Brabletz, Brian W. Simons, Thomas Reithmeier |
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| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
Epithelial-Mesenchymal Transition Motility Cell Growth Processes Biology Antigens CD Cell Movement Cell Line Tumor Glioma medicine Humans Neoplasm Invasiveness AC133 Antigen Epithelial–mesenchymal transition Wnt Signaling Pathway beta Catenin Glycoproteins Homeodomain Proteins Wnt signaling pathway Zinc Finger E-box-Binding Homeobox 1 LRP6 Cell Differentiation LRP5 medicine.disease Immunohistochemistry Cell biology Wnt Proteins HEK293 Cells Oncology Neoplastic Stem Cells Intercellular Signaling Peptides and Proteins Stem cell Signal transduction Glioblastoma Peptides Signal Transduction Transcription Factors |
| Zdroj: | Cancer Letters. 325:42-53 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2012.05.024 |
| Popis: | Here we show that activation of the canonical WNT/β-catenin pathway increases the expression of stem cell genes and promotes the migratory and invasive capacity of glioblastoma. Modulation of WNT signaling alters the expression of epithelial-to-mesenchymal transition activators, suggesting a role of this process in the regulation of glioma motility. Using immunohistochemistry in patient-derived glioblastoma samples we showed higher numbers of cells with intranuclear signal for β-catenin in the infiltrating edge of tumor compared to central tumor parenchyma. These findings suggest that canonical WNT/β-catenin pathway is a critical regulator of GBM invasion and may represent a potential therapeutic target. |
| Databáze: | OpenAIRE |
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