A new class of cis-monobactam derivatives bearing a sulfamoyloxymethyl or an N-alkylsulfamoyloxymethyl group at position 4: synthesis and antibacterial activity
| Autor: | R. Sperning, Grazia Angela Morandotti, Giuseppe Cascio, Giuseppe Satta, Renata Riva, Elso Manghisi, Giuseppe Guanti |
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| Rok vydání: | 1998 |
| Předmět: |
Staphylococcus aureus
Molecular Structure Sulfur Compounds Stereochemistry Pharmaceutical Science Chemical synthesis chemistry.chemical_compound Derivative (finance) chemistry Drug Discovery Pseudomonas aeruginosa medicine Lactam Escherichia coli Monobactam Antibacterial activity Monobactams medicine.drug Carumonam Antibacterial agent |
| Zdroj: | Farmaco (Societa chimica italiana : 1989). 53(3) |
| ISSN: | 0014-827X |
| Popis: | A new series of monobactam derivatives, bearing unsubstituted or N-monosubstituted sulfamoyloxymethyl groups in position 4 was synthesized either in racemic or in optically active form. Their in vitro antibacterial activity was tested in comparison with carumonam 1a and its methoxyimino derivative 1b. |
| Databáze: | OpenAIRE |
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