THE ROLE OF HLA TYPING IN RHEUMATIC DISEASES
| Autor: | L. Mascaretti, Elena Bevilacqua |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
Ankylosing spondylitis business.industry Arthritis Diagnostic algorithms Disease Human leukocyte antigen medicine.disease Rheumatoid arthritis Immunology medicine Genetic predisposition Clinical significance business HLA rheumatoid arthritis spondyloarthritis juvenile idiopathic arthritis |
| Zdroj: | Molecular and Experimental Biology in Medicine Volume 3 Issue 1 |
| ISSN: | 2584-671X |
| Popis: | Association between HLA-DR4 and rheumatoid arthritis (RA) has been known for 4 decades, and amino acid sites within HLA-DRB1 (11/13, 71, 74) are highly associated with RA. HLA is not useful for diagnosis or prognosis, but it may help predict severe and erosive disease. Since 90% of patients with ankylosing spondylitis (AS) and 50-70% of other spondyloarthritis (SpA) patients are HLA-B*27 positive, HLA is a stronghold of diagnostic algorithms. Genetic predisposition to juvenile idiopathic arthritis (JIA) is mainly due to HLA class II, and to a lesser extent to HLA class I. Although HLA plays a role in rheumatic disorders, its clinical relevance is not homogeneous. When classical biomarkers are lacking or in complex cases, HLA typing may provide support for the management of patients. |
| Databáze: | OpenAIRE |
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