[18F]Fluorodeoxyglucose – positron emission tomography/computed tomography improves staging in patients with high-risk muscle-invasive bladder cancer scheduled for radical cystectomy

Autor:	Oliver Patschan, Mats Bläckberg, Fredrik Liedberg, Carin Cronberg, Kerstin Lyttkens, Sigurdur Gudjonsson, Sabine Garpered, Helén Almquist, Petter Kollberg, Jakob Kleist
Rok vydání:	2015
Předmět:	Adult Male medicine.medical_specialty Urology medicine.medical_treatment Computed tomography Cystectomy Multimodal Imaging Cohort Studies Fluorodeoxyglucose F18 medicine Humans Prospective Studies Neoplasm Metastasis Stage (cooking) Hydronephrosis Aged Neoplasm Staging Aged 80 and over Carcinoma Transitional Cell Bladder cancer medicine.diagnostic_test business.industry Muscle Smooth Middle Aged medicine.disease Urinary Bladder Neoplasms Nephrology Positron emission tomography Positron-Emission Tomography Radiological weapon Female Radiology Tomography Radiopharmaceuticals Tomography X-Ray Computed business
Zdroj:	Scandinavian Journal of Urology. 49:296-301
ISSN:	2168-1813 2168-1805
DOI:	10.3109/21681805.2014.990053
Popis:	The aim of this study was to evaluate the clinical use of [(18)F]fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in addition to conventional preoperative radiological investigations in a defined group of patients with high-risk muscle-invasive bladder cancer.In total, 103 patients with high-risk muscle-invasive bladder cancer defined as stage T3/T4 disease or as stage T2 with hydronephrosis or high-risk histological features, who were provisionally scheduled to undergo cystectomy, were prospectively recruited to the study. The patients were referred to FDG-PET/CT in addition to standard preoperative investigation with computed tomography (CT). The final treatment decision was reached at a multidisciplinary conference based on all available information including the FDG-PET/CT findings.Compared to CT alone, FDG-PET/CT provided more supplemental findings suggesting malignant manifestations in 48 (47%) of the 103 patients. The additional FDG-PET/CT findings led to an altered provisional treatment plan in 28 out of 103 patients (27%), detection of disseminated bladder cancer and subsequent cancellation of the initially intended cystectomy in 16 patients, and identification of disseminated disease and treatment with induction chemotherapy before radical cystectomy in 12 patients.Preoperative FDG-PET/CT changed the treatment plan for a considerable proportion (27%) of the present patients. Accordingly, such examination can potentially improve the preoperative staging of cystectomy patients with high-risk features, and may also reduce the number of futile operations in patients with advanced disease who are beyond cure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11c84bc269c19d5a35dcd1c4f655545 https://doi.org/10.3109/21681805.2014.990053 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.