2,3-Dihydrobenzo-dioxine piperidine derivatives as potent and selective α2c antagonists

Autor:	Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Rok vydání:	2022
Předmět:	Piperidines Receptors Adrenergic alpha-2 Organic Chemistry Clinical Biochemistry Drug Discovery Pharmaceutical Science Molecular Medicine Dioxins Molecular Biology Biochemistry
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 69:128783
ISSN:	0960-894X
Popis:	In this manuscript, we report a series of benzodioxine methyl piperidine derivatives as highly potent and selective α2C antagonists by ligand design to improve the pharmacokinetics of a previous candidate molecule.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11c0582b9e57eabdf758db92785f82e https://doi.org/10.1016/j.bmcl.2022.128783 Zobrazit plný text záznamu Full Text from ScienceDirect