Fused ring aziridines as a facile entry into triazole fused tricyclic and bicyclic heterocycles
| Autor: | Fang Fang, Stephen C. Bergmeier, Megan E. Vogel, Jennifer V. Hines |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Azides Bicyclic molecule Molecular Structure Stereochemistry Organic Chemistry Aziridines Triazole Alkyne Triazoles Ring (chemistry) Biochemistry Cycloaddition chemistry.chemical_compound chemistry Cyclization Intramolecular force Alkynes Humans RNA Azide Physical and Theoretical Chemistry Oxazolidinones Tricyclic |
| Zdroj: | Organicbiomolecular chemistry. 10(15) |
| ISSN: | 1477-0539 |
| Popis: | The intramolecular dipolar cycloaddition of an azide with an alkyne has provided a useful entry into triazole fused tricyclic heterocycles containing both the triazole ring and the oxazolidin-2-one ring system. The requisite azido-alkynes have been prepared via a two-step sequence from fused ring aziridines. A series of 6–12 membered rings containing both the oxazolidinone and triazole rings have been prepared. These ring systems have been designed as conformationally restrained analogs of RNA-binding oxazolidinones. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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