Hand cortical bone mass and its associations with radiographic joint damage and fractures in 50-70 year old female patients with rheumatoid arthritis: cross sectional Oslo-Truro-Amsterdam (OSTRA) collaborative study
| Autor: | G Haugeberg, Anthony D. Woolf, Ben A. C. Dijkmans, Till Uhlig, Willem F. Lems, T K Kvien, MC Lodder, Ragnhild Ørstavik |
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| Přispěvatelé: | VU University medical center |
| Rok vydání: | 2004 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Concise Report Radiography Immunology Dentistry General Biochemistry Genetics and Molecular Biology Arthritis Rheumatoid Fractures Bone Absorptiometry Photon Rheumatology Bone Density Internal medicine medicine Immunology and Allergy Humans Osteoporosis Postmenopausal Femoral neck Aged Bone mineral business.industry Femur Neck musculoskeletal neural and ocular physiology Middle Aged medicine.disease musculoskeletal system Hand Spine medicine.anatomical_structure Cross-Sectional Studies Logistic Models Rheumatoid arthritis Joint damage Cortical bone Female Radiology business Digital X-ray radiogrammetry |
| Zdroj: | Annals of the Rheumatic Diseases, 63(10), 1331-4. BMJ Publishing Group Haugeberg, G, Lodder, M C, Lems, W F, Uhlig, T, Orstavik, RE, Dijkmans, B A C, Kvien, TK & Woolf, AD 2004, ' Hand cortical bone mass and its associations with radiographic joint damage and fractures in 50-70 year old female patients with rheumatoid arthritis: cross sectional Oslo-Truro-Amsterdam (OSTRA) collaborative study. ', Annals of the Rheumatic Diseases, vol. 63, no. 10, pp. 1331-4 . https://doi.org/10.1136/ard.2003.015065 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2003.015065 |
| Popis: | Objective: To investigate the relationship between hand bone mineral density (BMD) and radiographic joint damage, and between hand BMD and fractures in 50–70 year old women with longstanding RA. Methods: Demographic, clinical data, and imaging data on hand radiographs and Genants vertebral deformity score on spine radiographs were collected from 135 women with RA of ⩾5 years, recruited from three European rheumatology clinics. Metacarpal hand BMD was measured by digital hand x ray radiogrammetry (DXR), and hip and lumbar spine BMD by dual x ray absorptiometry (DXA). Multiple regression analyses were used to examine associations between hand BMD and radiographic joint damage, and hand BMD and fractures. Results: Hand BMD was strongly and independently associated with radiographic hand joint damage in a linear regression model adjusted for age, centre, BMI, disease duration, RF, 18 deformed joint count, ESR, and femoral neck BMD. In a multivariate logistic regression model adjusted for relevant variables, hand BMD and femoral neck BMD, but not spine BMD, were independently associated with vertebral deformities and with non-vertebral fractures. Conclusion: BMD measured by DXR on conventional hand radiographs in patients with RA may potentially be used as an indicator of joint damage and of vertebral and non-vertebral fracture risk. |
| Databáze: | OpenAIRE |
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