Clinical and laboratory features of HTLV-I asymptomatic carriers and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis from the Brazilian Amazon

Autor: Massanobu Takatani, Nelson Abrahim Fraiji, Myuki Esashika Crispim, Dagmar Kiesslich, Mariane Martins de Araújo Stefani
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
lcsh:Arctic medicine. Tropical medicine
CSF glucose
lcsh:RC955-962
Gastroenterology
Neopterin
HAM/TSP patients
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cerebrospinal fluid
immune system diseases
Internal medicine
Tropical spastic paraparesis
medicine
Humans
Aged
Human T-lymphotropic virus 1
HTLV-I carriers
business.industry
Case-control study
virus diseases
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Paraparesis
Tropical Spastic
030104 developmental biology
Infectious Diseases
chemistry
Potential biomarkers
Case-Control Studies
Immunology
Carrier State
Htlv i associated myelopathy
Female
Original Article
business
Asymptomatic carrier
030217 neurology & neurosurgery
Biomarkers
Brazil
Zdroj: Revista do Instituto de Medicina Tropical de São Paulo; Vol. 59 (2017); e5
Revista do Instituto de Medicina Tropical de São Paulo; v. 59 (2017); e5
Revista do Instituto de Medicina Tropical de São Paulo
Instituto de Medicina Tropical (IMT)
instacron:IMT
Revista do Instituto de Medicina Tropical de São Paulo, Vol 59, Iss 0
Revista do Instituto de Medicina Tropical de São Paulo, Volume: 59, Article number: e5, Published: 03 APR 2017
ISSN: 1678-9946
0036-4665
Popis: Clinical and laboratory parameters including blood and cerebrospinal fluid (CSF) neopterin were investigated in human-T-lymphotropic-virus-type-I associated-myelopathy/tropical-spastic-paraparesis-HAM/TSP and in HTLV-I carriers. HAM/TSP (n = 11, 2 males/9 females, median age = 48 years), recently diagnosed HTLV-I carriers (n = 21, 15 females/6 males, median age = 44 years), healthy individuals (n = 20, 10 males/10 females, median age = 34.6 years) from the Brazilian Amazon (Manaus, Amazonas State) were investigated. Neopterin was measured (IBL ELISA Neopterin, Germany) in serum samples of all the participants, in CSF of 9 HAM/TSP patients as well as in 6 carriers. In HAM/TSP patients, CSF cell counts, protein and glucose were measured, the Osame’s motor-disability-score/OMDS was determined, and brain/spinal cord magnetic-resonance-imaging (MRI) was performed. HAM/TSP patients had normal CSF glucose, leukocyte counts; and normal protein levels predominated. Brain-MRI showed white-matter lesions in 7 out of 11 HAM/TSP patients. OMDS varied from 2-8: 9 were able to walk, 2 were wheel-chair-users. The median serum neopterin concentration in HAM/TSP patients was 6.6 nmol/ L; min. 2.8- max. 12.5 nmol/ L); was lower in carriers (4.3 nmol/L; min. 2.7- max. 7.2 nmol/ L) as well as in healthy participants (4.7 nmol/ L; min. 2.7- max. 8.0 nmol/ L) (p < 0.05). CSF neopterin concentrations in HAM/TSP patients were higher than in serum samples, and higher compared to carriers (p < 0.05). Carriers had similar serum-CSF neopterin concentrations compared to healthy participants. Variable clinical and laboratory profiles were seen in HAM/TSP patients, however our results support the neopterin measurement as a potential biomarker of disease activity.
Databáze: OpenAIRE
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