A poor and delayed anti-SARS-CoV2 IgG response is associated to severe COVID-19 in children
| Autor: | María Marcó del Pont, Lorena I. Gimenez, Norberto De Carli, Maria Laura Polo, Laura Alvarez, Melina Salvatori, Jorge Geffner, Augusto Varese, Juan Martín Gómez Penedo, Silvina Raiden, Eugenia M. Takata, María Revetria, Ana L. Alcalde, María Temis Agosta, Patricia Coll, Hernán Pérez, Macarena Uranga, Nancy Simaz, Constanza Russo, Mariela García, Patricia G Suárez, Ana Ceballos, Carola Bayle, Fernando Ferrero, María J. Chiolo, Susana Villa Nova, María José Rolón, Lourdes Arruvito, Héctor Cairoli, Mariam Sarli, Sandra Di Lalla, Inés Sananez, Emilia Cohen, Graciela Mosquera, Gabriela Gregorio, Jorge Lattner, Nicolás A. Grisolía, Claudia Meregalli, María J. Bruera, María P. Holgado, Silvia C. Algieri, Mariela F. Pérez, Valeria Nivela, Vanesa Seery, Claudio Piccardo, Patricia Tuccillo, Daniela Filippo, Myriam Nuñez, Carolina Davenport |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Medicine (General) Disease severity antibodies T cells Argentina Disease Antibodies Viral medicine.disease_cause Asymptomatic General Biochemistry Genetics and Molecular Biology Immunoglobulin G R5-920 Humans Medicine Child Coronavirus biology SARS-CoV-2 business.industry COVID-19 Infant General Medicine medicine.disease Systemic Inflammatory Response Syndrome Pediatric COVID-19 Systemic inflammatory response syndrome Immunoglobulin M Child Preschool Antibody Formation Immunology Cohort biology.protein Cytokines Female medicine.symptom Antibody business Research Paper |
| Zdroj: | EBioMedicine, Vol 72, Iss, Pp 103615-(2021) EBioMedicine |
| ISSN: | 2352-3964 |
| Popis: | Background Most children and youth develop mild or asymptomatic disease during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, a very small number of patients suffer severe Coronavirus induced disease 2019 (COVID-19). The reasons underlying these different outcomes remain unknown. Methods We analyzed three different cohorts: children with acute infection (n=550), convalescent children (n=138), and MIS-C (multisystem inflammatory syndrome in children, n=42). IgG and IgM antibodies to the spike protein of SARS-CoV-2, serum-neutralizing activity, plasma cytokine levels, and the frequency of circulating Follicular T helper cells (cTfh) and plasmablasts were analyzed by conventional methods. Findings Fifty-eight percent of the children in the acute phase of infection had no detectable antibodies at the time of sampling while a seronegative status was found in 25% and 12% of convalescent and MIS-C children, respectively. When children in the acute phase of the infection were stratified according disease severity, we found that contrasting with the response of children with asymptomatic, mild and moderate disease, children with severe COVID-19 did not develop any detectable response. A defective antibody response was also observed in the convalescent cohort for children with severe disease at the time of admission. This poor antibody response was associated to both, a low frequency of cTfh and a high plasma concentration of inflammatory cytokines. Interpretation A weak and delayed kinetic of antibody response to SARS-CoV-2 together with a systemic pro-inflammatory profile characterize pediatric severe COVID-19. Because comorbidities are highly prevalent in children with severe COVID-19, further studies are needed to clarify their contribution in the weak antibody response observed in severe disease. Funding National Agency for Scientific and Technological Promotion from Argentina (IP-COVID-19-0277 and PMO-BID-PICT2018-2548). |
| Databáze: | OpenAIRE |
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