Thienopyrimidine-based P2Y12 platelet aggregation inhibitors

Autor:	Hayat K. Rahman, Tenbrink Ruth E, Barbara A. Schweitzer, Rita M. Huff, Steven W. Kortum, Gopichand Yalamanchili, Rhonda M. Lachance, Ennis Michael D
Rok vydání:	2009
Předmět:	Platelet Aggregation medicine.drug_class Clinical Biochemistry Pharmaceutical Science Carboxamide Plasma protein binding Biochemistry Chemical synthesis Structure-Activity Relationship P2Y12 Fibrinolytic Agents Drug Discovery Purinergic P2 Receptor Antagonists medicine Humans Structure–activity relationship Platelet Molecular Biology Receptors Purinergic P2 Chemistry Organic Chemistry Receptors Purinergic P2Y12 In vitro Pyrimidines Molecular Medicine Platelet aggregation inhibitor Platelet Aggregation Inhibitors Protein Binding
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 19:5919-5923
ISSN:	0960-894X
Popis:	Herein we describe the design and synthesis of a novel series of potent thienopyrimidine P2Y12 inhibitors and the negative impact protein binding has on the inhibition of platelet aggregation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1168e97666a6aa5449358436b682ec5 https://doi.org/10.1016/j.bmcl.2009.08.059 Zobrazit plný text záznamu Full Text from ScienceDirect