The Outcome of Children With Malignant Bone Tumors: A Single-Center Experience
| Autor: | Omidreza Zekavat, Ali Sarfaraz, Tahereh Zarei, Sezaneh Haghpanah, Mohammadreza Bordbar, Soheila Zareifar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Southern Iran business.industry Hazard ratio medicine.disease Single Center survival Pediatrics bone neoplasms RJ1-570 Metastasis osteosarcoma Internal medicine Pediatrics Perinatology and Child Health Cohort Medicine Osteosarcoma Original Research Article Sarcoma Risk factor business Ewing sarcoma |
| Zdroj: | Global Pediatric Health, Vol 8 (2021) Global Pediatric Health |
| Popis: | Malignant bone tumors (MBT) account for 3% to 5% of cancers in children younger than 15 years. We aimed to report the outcome of children with MBT in 10 years in Southern Iran. During the study period, 100 patients (57 Osteosarcoma, 43 Ewing sarcoma) with an M/F ratio of 1.56 and a median age of 13.8 years (3.8-17.9) were diagnosed. Metastasis occurred in 27% of patients, mostly in the first 3 months of diagnosis. The mean survival time of MBT altogether was 94.1 months (95% CI: 86.5-101.7). The 5-year overall survival and event-free survivals were 85.2% (95% CI: 74%-91.8%) and 69.2% (95% CI: 56%-79%), respectively. Metastasis was the only independent risk factor of death in our study cohort (Hazard ratio 36.7, 95% CI: 4.8-282.6, P = .001) MBT in children mostly occur in adolescent boys. About one-third of them become metastatic, which is significantly associated with poor outcomes. |
| Databáze: | OpenAIRE |
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