Donor Cytomegalovirus Transmission Patterns in Solid Organ Transplant Recipients With Primary Infection
| Autor: | Maria E. Hasing, Xiao-Li Pang, Jutta K. Preiksaitis, Curtis Mabilangan |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
030106 microbiology Congenital cytomegalovirus infection Cytomegalovirus Group A Group B 03 medical and health sciences Genotype medicine Humans Immunology and Allergy Retrospective Studies Strain (chemistry) Coinfection Transmission (medicine) business.industry Organ Transplantation medicine.disease Virology Transplant Recipients 030104 developmental biology Infectious Diseases Cytomegalovirus Infections Solid organ transplantation business |
| Zdroj: | The Journal of Infectious Diseases. 223:827-837 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiaa450 |
| Popis: | Background The epidemiology of single versus multiple cytomegalovirus (CMV) strain transmission from donor (D+) to seronegative solid organ transplant (SOT) recipients (R−) is uncertain, as is whether “relapsing” recipient infection represents changing strain predominance when multiple strains are transmitted. Here we characterized CMV strain transmission patterns in D+/R− SOT recipients. Methods We studied pairs or groups of D+/R− SOT recipients who received organs from a common donor (group A) and recipients who experienced ≥2 waves of CMV DNAemia (group B). CMV in plasma was characterized by genotype-specific real-time PCR for genes gB and gH. Results Single concordant genotypes were identified in 12 of 18 recipient pairs/group sharing a common donor (group A); at least 6 of 18 (33%) donors transmitted > 1 strain. A single CMV strain was detected in 14 of 15 recipients in group B; only 1 recipient had coinfection. A shift in CMV strain predominance occurred after the first posttransplant year in at least 4 recipients with coinfection. Conclusions Using a common donor approach, we confirmed that multiple CMV strain transmission from donors to R− SOT recipients is not uncommon. D+/R− SOT recipients with CMV coinfection can undergo changes in strain predominance in late waves of CMV DNAemia. |
| Databáze: | OpenAIRE |
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