Does Roller Pump–Induced Pulsatile CPB Perfusion Affect Microvascular Fluid Shifts and Tissue Perfusion?
| Autor: | Paul Husby, Øyvind Sverre Svendsen, Venny Lise Kvalheim, Bjørg Elvevoll, Arve Mongstad, Steinar Lundemoen, Ketil Grong |
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| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
Oncotic pressure Swine Pulsatile flow Peristaltic pump 030204 cardiovascular system & hematology Hematocrit law.invention Microcirculation 03 medical and health sciences 0302 clinical medicine law Cardiopulmonary bypass medicine Animals Fluid Shifts Cardiopulmonary Bypass medicine.diagnostic_test business.industry Extravasation Disease Models Animal 030228 respiratory system Pulsatile Flow Anesthesia Female Surgery Heart-Assist Devices Cardiology and Cardiovascular Medicine business Perfusion |
| Zdroj: | The Annals of Thoracic Surgery. 102:564-572 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/j.athoracsur.2016.02.005 |
| Popis: | Background Pulsatile versus nonpulsatile cardiopulmonary bypass (CPB) perfusion remains debated. Beneficial effects on tissue perfusion, inflammation, and microvascular fluid exchange have been linked to pulsatile perfusion by some investigators and denied by others. This study evaluated fluid extravasation and tissue perfusion during nonpulsatile or pulsatile roller pump–induced CPB perfusion. Methods Fourteen pigs underwent roller pump–induced pulsatile (n = 7) or nonpulsatile CPB perfusion (n = 7) for 90 minutes. Fluid input/losses, colloid osmotic pressures (plasma/interstitium), hematocrit, serum electrolytes, serum proteins, tissue perfusion, and total tissue water content were measured, and plasma volume and fluid extravasation were calculated. Results Fluid additions/losses, plasma volume, and fluid extravasation changed similarly in both groups during CPB with no between-group differences. Neither was between-group differences observed for tissue perfusion and total tissue water content, with one exception. Total tissue water content of the right (3.92 ± 0.26 versus 4.32 ± 0.28 g/g dry weight) and left ventricle (4.02 ± 0.25 versus 4.33 ± 0.24 g/g dry weight) was lowered in the pulsatile group. Conclusions No important differences were found between pulsatile and nonpulsatile CPB perfusion for microvascular fluid balance and tissue perfusion. |
| Databáze: | OpenAIRE |
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