A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells
| Autor: | Regula Stuber Roos, Bernhard Moser, Lisa M. Ebert, Katharina Willimann, Andrea Blaser, Pius Loetscher, Patrick Schaerli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Regulatory T cell
T cell T-Lymphocytes Immunology Receptors Lymphocyte Homing Biology migration Article Receptors CCR8 Immunophenotyping Interleukin 21 memory T cells Antigens CD medicine Immunology and Allergy Cytotoxic T cell Humans Antigen-presenting cell Cells Cultured Skin integumentary system chemokine T helper cell peripheral tissue Natural killer T cell R1 medicine.anatomical_structure QR180 Cytokines Receptors Chemokine Memory T cell Immunologic Memory CCR8 |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Effective immune surveillance is essential for maintaining protection and homeostasis of peripheral tissues. However, mechanisms controlling memory T cell migration to peripheral tissues such as the skin are poorly understood. Here, we show that the majority of human T cells in healthy skin express the chemokine receptor CCR8 and respond to its selective ligand I-309/CCL1. These CCR8(+) T cells are absent in small intestine and colon tissue, and are extremely rare in peripheral blood, suggesting healthy skin as their physiological target site. Cutaneous CCR8(+) T cells are preactivated and secrete proinflammatory cytokines such as tumor necrosis factor-alpha and interferon-gamma, but lack markers of cytolytic T cells. Secretion of interleukin (IL)-4, IL-10, and transforming growth factor-beta was low to undetectable, arguing against a strict association of CCR8 expression with either T helper cell 2 or regulatory T cell subsets. Potential precursors of skin surveillance T cells in peripheral blood may correspond to the minor subset of CCR8(+)CD25(-) T cells. Importantly, CCL1 is constitutively expressed at strategic cutaneous locations, including dermal microvessels and epidermal antigen-presenting cells. For the first time, these findings define a chemokine system for homeostatic T cell traffic in normal human skin. |
| Databáze: | OpenAIRE |
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