Lack of Improvement of Sperm Characteristics in Obese Males After Obesity Surgery Despite the Beneficial Changes Observed in Reproductive Hormones
| Autor: | Berniza Calderón, Héctor F. Escobar-Morreale, José I. Botella-Carretero, Julio Galindo, José Manuel González Casbas, Antonia Martín-Hidalgo, Lydia Huerta |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Bariatric Surgery 030209 endocrinology & metabolism Semen analysis Body Mass Index 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Medicine Humans Insulin Inhibins Testosterone Postoperative Period Gonadal Steroid Hormones Infertility Male Nutrition and Dietetics medicine.diagnostic_test business.industry Hypogonadism Middle Aged medicine.disease Prognosis Sperm Obesity Spermatozoa Obesity Morbid Semen Analysis Endocrinology Treatment Outcome 030211 gastroenterology & hepatology Surgery business Spermatogenesis hormones hormone substitutes and hormone antagonists Hormone Follow-Up Studies |
| Zdroj: | Obesity surgery. 29(7) |
| ISSN: | 1708-0428 |
| Popis: | Even though obesity surgery normalizes circulating testosterone concentrations in males with obesity-associated secondary hypogonadism, its impact on spermatogenesis remains controversial. We aimed to evaluate sperm characteristics in obese men after bariatric surgery as well as changes in reproductive hormones. Twenty severely obese men (body mass index (BMI) ≥ 35 kg/m2) were evaluated before and 2 years after bariatric surgery. The serum was assayed for insulin, leptin, kisspeptin, and inhibin B, among other hormones. Homeostasis model assessment of insulin resistance (HOMA-IR) was estimated. We used World Health Organization reference values for sperm analysis. After surgery, serum total testosterone, calculated free testosterone, inhibin B, and kisspeptin increased, whereas fasting insulin, HOMA-IR, and leptin concentrations decreased. Despite these improvements, sperm volume showed a small decrease after surgery, while the rest of sperm characteristics remained mostly unchanged. Abnormal sperm concentration persisted in 60% of the patients. Sperm characteristics may not improve after bariatric surgery despite the beneficial changes of reproductive hormones. |
| Databáze: | OpenAIRE |
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