Height, weight, IGF-I, IGFBP-3 and thyroid functions in prepubertal children with attention deficit hyperactivity disorder: effect of methylphenidate treatment
| Autor: | Fatih Ozbay, Goncagül Haklar, M Yanki Yazgan, Abdullah Bereket, Serap Turan, M Goksin Karaman |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Thyroid Hormones genetic structures Endocrinology Diabetes and Metabolism medicine.medical_treatment Thyroid Gland Growth hormone Body weight Endocrinology Internal medicine Medicine Attention deficit hyperactivity disorder Humans Insulin-Like Growth Factor I Child business.industry Methylphenidate Growth factor Thyroid Body Weight Case-control study Infant Newborn Infant medicine.disease Body Height medicine.anatomical_structure Insulin-Like Growth Factor Binding Protein 3 Attention Deficit Disorder with Hyperactivity Thyroid hormones Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Central Nervous System Stimulants business medicine.drug |
| Zdroj: | Hormone research. 63(4) |
| ISSN: | 0301-0163 |
| Popis: | Objective: To investigate if there are any disease-related or methylphenidate-induced aberrations in growth parameters, growth hormone insulin-like growth factor (IGF)-I, IGFBP-3 axis and the thyroid function tests in children with attention deficit hyperactivity disorder (ADHD). Methods: Newly diagnosed and untreated prepubertal children with ADHD were longitudinally followed before and approximately every 4 months after methylphenidate treatment for up to 16 months. Height SDS, weight SDS, BMI SDS, serum GH, IGF-I, IGFBP-3, T4, free T4, T3, and TSH were measured at each visit. Results: All of the examined parameters were within normal limits for age before treatment. Methylphenidate treatment did not significantly affect SDS of height, weight, BMI, IGF-I and IGFBP-3 in the long run. Serum T4 and free T4 levels showed modest reductions within normal limits in a time-dependent manner. Conclusions: Prepubertal children with ADHD had normal height, weight, BMI, serum IGF-I and IGFBP-3 and thyroid functions. Methylphenidate treatment had no sustained effects on growth parameters, IGF-I and IGFBP-3 during the follow-up period of this study. However, it caused a mild decrease in total and free T4 which may warrant further monitoring. |
| Databáze: | OpenAIRE |
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