Cytogenetic findings in acute promyelocytic leukaemia. A report of 25 cases
| Autor: | M. R. De Cuia, R. Gastaldi, A. Franchi, Bruno Dallapiccola, Giuliana Alimena, Franco Mandelli, E. Gallo, Mauro Nanni |
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| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Chromosomal translocation Biology Translocation Genetic medicine Humans Child Cells Cultured Chromosomes Human 16-18 Chromosome Karyotype Hematology Direct Technique Middle Aged Leukemia Myeloid Acute medicine.anatomical_structure Karyotyping Female Acute promyelocytic leukaemia Bone marrow Chromosomes Human 13-15 Granulocytes |
| Zdroj: | Scopus-Elsevier |
| Popis: | Cytogenetic analyses of bone marrow cells were carried out by means of direct technique and short-term cultures in 25 acute promyelocytic leukaemia (APL) patients. 16 were affected by the hypergranular form and 9 by the M3-variant. The t(15;17) was documented at diagnosis in 15 patients. In addition, 2 cases, in which an M3 morphology and a normal karyotype on direct preparation were found at diagnosis, disclosed the chromosome anomaly in cultured cells at relapse, in concomitance with a change of blast morphology to the M3-variant. However, the t(15;17) was a consistent feature in 5 of the 15 patients with cells analysed on direct preparations only and in all cases who had successful bone marrow cultures. Overall, the 15;17 translocation was detected in 7 out of 9 patients with the M3-variant and in 8 out of 16 patients with typical M3. Whenever the chromosome preparations were made after culture, 7/7 had the translocation in the M3-V group and 5/5 in the M3 group. No obvious differences in clinical features or outcome were evident in the patients, irrespective of their cytogenetic findings. |
| Databáze: | OpenAIRE |
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