Neuropsychiatric morbidity in focal epilepsy
| Autor: | Sophia J. Adams, Christine Kilpatrick, Dennis Velakoulis, Michael R. Salzberg, Terence J. O'Brien, John H. Lloyd |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Psychosis Temporal lobe Central nervous system disease 03 medical and health sciences Epilepsy 0302 clinical medicine medicine History of depression Humans 030212 general & internal medicine Psychiatry Depression (differential diagnoses) Depressive Disorder medicine.diagnostic_test Mental Disorders Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Epilepsy syndromes Female Epilepsies Partial Epidemiologic Methods Psychology |
| Zdroj: | British Journal of Psychiatry. 192:464-469 |
| ISSN: | 1472-1465 0007-1250 |
| DOI: | 10.1192/bjp.bp.107.046664 |
| Popis: | BackgroundPrevious work has identified elevated prevalence rates for psychiatric disorders in individuals with medically refractory focal epilepsy, particularly temporal lobe epilepsy. Many studies were undertaken before the advent of video electroencephalogram monitoring (VEM) and magnetic resonance imaging (MRI).AimsTo investigate which characteristics of the focal epilepsy syndromes are associated with the presence of depression or psychosis.MethodThree hundred and nineteen individuals with focal epilepsy admitted for VEM were seen over an 11-year period. The lifetime history of depression and psychosis, epileptic site, laterality and type of lesion were determined by clinical assessment, VEM and MRI scan.ResultsThere was a significant association between the prevalence of depressive symptoms and non-lesional focal epilepsy. There were no significant differences in prevalence of neuropsychiatric disorders between the groups with temporal lobe epilepsy and those with extratemporal lobe epilepsy.ConclusionsThese findings contrast with previous findings in smaller cohorts. The association between non-lesional focal epilepsy and depression may be due to the effects of a more diffuse epileptogenic area. |
| Databáze: | OpenAIRE |
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