Urinary N1, N12-diacetylspermine is a non-invasive marker for the diagnosis and prognosis of non-small-cell lung cancer
| Autor: | Kyoko Hiramatsu, Keiichi Takahashi, Yusuke Takahashi, Hirotoshi Horio, Shun-suke Moriya, Masao Kawakita, Koji Sakaguchi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Pathology Lung Neoplasms Urinary system urine diacetylspermine Internal medicine Carcinoma Non-Small-Cell Lung medicine tumour marker Biomarkers Tumor Humans Stage (cooking) Lung cancer Pathological Molecular Diagnostics Early Detection of Cancer Aged Aged 80 and over business.industry Proportional hazards model Hazard ratio Middle Aged medicine.disease Prognosis respiratory tract diseases prognostic indicator non-small-cell lung cancer Adenocarcinoma Biomarker (medicine) Regression Analysis Female Spermine business |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Background: Early detection of non-small-cell lung cancer (NSCLC) and accurate prognostic risk assessment could improve patient outcome. We examined the significance of urinary N1, N12-diacetylspermine (DiAcSpm) in the detection and prognostic stratification of NSCLC patients. Methods: A DiAcSpm/cutoff ratio (DASr) was established for 260 NSCLC patients, 99 benign lung disease patients, and 140 healthy volunteers, using colloidal gold aggregation methods. The DASr was compared between patients and healthy controls, and the prognostic significance of DASr was examined. Results: The median urinary DASr of NSCLC patients was significantly higher than that of healthy controls (0.810 vs 0.534, P |
| Databáze: | OpenAIRE |
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