Antilithiatic activity of a non-pharmacopoeial Unani formulation in chemically induced urolithiasis in rats
| Autor: | Shariq Shamsi, Shaista Parveen, Abdul Wadud, Rehana Parveen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Physalis
Tribulus Sodium Adiantum chemistry.chemical_element Urine Calcium Kidney 030226 pharmacology & pharmacy Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Urolithiasis Animals Medicine Creatinine Calcium Oxalate biology Traditional medicine Plant Extracts business.industry biology.organism_classification Urinary calcium Rats Complementary and alternative medicine chemistry Distilled water 030220 oncology & carcinogenesis Urea business Apiaceae Phytotherapy |
| Zdroj: | Journal of Complementary and Integrative Medicine. 18:685-694 |
| ISSN: | 1553-3840 |
| Popis: | Objectives Parshioshan (Adiantum capillus-veneris L.), Duqu (Peucedanum grande C.B. Clarke), Kaknaj (Physalis alkekengi L.) and Kharekhasak (Tribulus terresteris L.) have been selected for this study as they have been associated with medicinal actions for litholytic activity. Methods The experiment was carried out in Sprague Dawley rats divided into seven groups, serving as plain control, disease control, standard control, curative A and B and preventive A and B groups. Animals of plain control received distilled water. Remaining six groups received Ethylene glycol 0.75% and Ammonium chloride 1% by adding in the drinking water for the first three days followed by 0.75% Ethylene glycol for 18 days. From 8th day till 21st day, standard control received Cystone in the dose of 750 mg/kg. Preventive and curative test groups were treated with hydroalcoholic extract of the test drug in the dose of 132 mg/kg and 264 mg/kg from 1st to 21st day and 8th to 21st day of calculi induction. Results Test drug reduced the number of calcium oxalate crystals in the urine; the level of urinary calcium, creatinine, magnesium, phosphorus, sodium and chloride decreased significantly in standard and test groups. The urine volume increased significantly in all the test groups. The level of serum calcium, urea, phosphorus and creatinine were significantly reduced in all the test groups. Conclusions These results indicated that the test drug reduced and prevented the growth of urinary stones. Moreover, the test drug also possessed significant antiurolithiatic activity. However, the protective effect was found more than its curative effect. |
| Databáze: | OpenAIRE |
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