Cephazolin Treatment of Pneumococcal Pneumonia and Urinary Tract Infections
| Autor: | J G Tilles, M Kilpatrick, L. D. Thrupp, Thomas C. Cesario |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
medicine.medical_specialty
Urinary system Renal function Microbial Sensitivity Tests Bacteriuria Urine 030204 cardiovascular system & hematology Gastroenterology Drug Administration Schedule Pneumococcal Infections 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Cefazolin medicine Humans Lung Abscess 030212 general & internal medicine Creatinine biology business.industry Pneumonia General Medicine Enterobacter biology.organism_classification medicine.disease Cephalosporins Pleural Effusion Enterococcus chemistry Urinary Tract Infections Pneumococcal pneumonia business Half-Life |
| Zdroj: | Scottish Medical Journal. 20:248-254 |
| ISSN: | 2045-6441 0036-9330 |
| DOI: | 10.1177/003693307502000515 |
| Popis: | Ten cases of pneumococcal pneumonia were treated with cephazolin 500 mg. q8h for at least 5 days. In every case therapy was accompanied by clinical improvement and eradication of the organism. Ten patients with E. coli bacteriuria (5 symptomatic) were treated with cephazolin 500 mg. q12h for 7 to 10 days. In every case the pathogen was eliminated during therapy but in one case bacteriologic relapse occurred following cessation of therapy. In 10 cases of bacteriuria caused by P. mirabilis, Klebsiella sp, Enterobacter, and Enterococcus, the urine became sterile during treatment, but relapse was common. Initial and final creatinine clearances obtained in 29 patients who received an average of 12.9 g. of cephazolin showed no tendency toward loss of renal function. Serial serum levels of cephazolin were determined following the first 500 mg. dose in 18 patients. The peak serum level occurred at one hour with a serum half life of approximately 2.2 hours. For 13 of these 18 patients serial serum levels were also obtained following the last dose of cephazolin. At this time the mean peak level occurred at 2 hours but again the serum half life was approximately 1.9 hours. |
| Databáze: | OpenAIRE |
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