Asymmetric synthesis of novel α-amino acids with β-branched side chains

Autor:	Boyd L. Harrison, Dennis Kubrak, Kimberly Sogi, George Diamantidis, Anthony F. Kreft, Zheng Wang, Zhang Minsheng, Scott Christian Mayer, Lynn Resnick, Alex Porte
Rok vydání:	2007
Předmět:	chemistry.chemical_classification Stereochemistry Chemistry Pharmaceutical Organic Chemistry Clinical Biochemistry Chemistry Organic Molecular Conformation Enantioselective synthesis Pharmaceutical Science General Medicine Biochemistry Chemical synthesis Amino acid Models Chemical chemistry Feature (computer vision) Drug Design Drug Discovery Side chain Molecular Medicine Amino Acids Aliphatic compound Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 17:2401-2403
ISSN:	0960-894X
Popis:	An asymmetric synthesis of alpha-amino acids with novel beta-branched side chains has been implemented. The syntheses feature a p-toluenesulfinylimine induced chiral Strecker approach and were found to be applicable to the introduction of both aliphatic and aromatic beta-branched sidechains for preparation of previously unknown alpha-amino acids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10629f0ae1e5e7fe396806c331fa68b https://doi.org/10.1016/j.bmcl.2007.02.041 Zobrazit plný text záznamu Full Text from ScienceDirect