Comparison of postoperative infection and graft uptake rate using single dose of intravenous co-amoxiclav versus no antibiotic in children undergoing myringoplasty: A randomized controlled trial
| Autor: | Rajendra Prasad Guragain, Prakash Khanal, C L Bhusal |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.drug_class Antibiotics Amoxicillin-Potassium Clavulanate Combination law.invention 03 medical and health sciences Myringoplasty 0302 clinical medicine Postoperative Complications Randomized controlled trial law 030225 pediatrics medicine Postoperative infection Humans Prospective Studies Uptake rate 030223 otorhinolaryngology Trial registration Child Tympanic Membrane Perforation business.industry Significant difference General Medicine Surgery Anti-Bacterial Agents Otitis Media Treatment Outcome Otorhinolaryngology Pediatrics Perinatology and Child Health Chronic Disease Administration Intravenous Female Intraoperative Period business Follow-Up Studies |
| Zdroj: | International journal of pediatric otorhinolaryngology. 131 |
| ISSN: | 1872-8464 |
| Popis: | Objectives To compare postoperative infection and graft uptake rate using single dose of intravenous co-amoxiclav versus no antibiotic in children undergoing myringoplasty. Methods This is a prospective, randomized controlled study conducted in children of age 6–15 years with chronic otitis media (COM) mucosal, inactive type undergoing myringoplasty. Postoperative infection over a period of 4 weeks and status of graft at or around 3 months after surgery was studied as outcome measure. Results Fifty five out of sixty children completed follow-up. The overall postoperative infection rate was 5.4%. Postoperative infection rate was 3.5% in children receiving prophylactic antibiotic and 7.4% in children receiving no antibiotic. There was no statistically significant difference in postoperative infection between two groups (P > 0.05). The overall graft uptake rate was 87.27%. It was 85.7% in antibiotic used group and 88.8% in non-antibiotic group with no statistically significant difference (P > 0.05). Conclusions Postoperative infection following myringoplasty in children is uncommon as it is a clean type of surgery. There was no statistically significant difference in postoperative infection and graft uptake rate by the use of prophylactic antibiotic in the intraoperative period. This study shows no benefit of a prophylactic antibiotic on postoperative infection or graft success in myringoplasty in children. Trial registration number NCT03700814. |
| Databáze: | OpenAIRE |
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