Serum type III procollagen peptide in alcoholic liver disease and idiopathic hemochromatosis: its relationship to hepatic fibrosis, activity of the disease and iron overload
| Autor: | Paolo A. Bianchi, Dino Martines, Giorgio Annoni, Alberto Piperno, Massimo Colombo, Dario Conte, Maria Francesca Donato, Maria Grazia Zaramella, Claudio Tiribelli |
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| Přispěvatelé: | Massimo Colombo, M. D., Annoni, Giorgio, Donato, Maria Francesca, Conte, Dario, Martines, Dino, Zaramella, Maria Grazia, Bianchi, Paolo A., Piperno, Alberto, Tiribelli, Claudio, Colombo, M, Annoni, G, Donato, M, Conte, D, Martines, D, Zaramella, M, Bianchi, P, Piperno, A, Tiribelli, C |
| Rok vydání: | 1985 |
| Předmět: |
Adult
Liver Cirrhosis Male Pathology medicine.medical_specialty Alcoholic liver disease Cirrhosis Hemochromatosi Liver Cirrhosi Radioimmunoassay Gastroenterology Liver disease Peptide Fragment Fibrosis Internal medicine medicine Humans Liver Diseases Alcoholic Hemochromatosis Aged Ferritin Hepatology business.industry Middle Aged medicine.disease Peptide Fragments Procollagen peptidase Liver Ferritins Female Steatosis Hepatic fibrosis business Procollagen Human |
| Zdroj: | Hepatology (Baltimore, Md.). 5(3) |
| ISSN: | 0270-9139 |
| Popis: | To assess the value of type III procollagen peptide (sPIIIP) as a marker of hepatic fibrosis, sera from 73 patients with alcohol-related liver disease and 30 patients with idiopathic hemochromatosis (IHC) were studied by a specific radioimmunoassay. sPIIIP was increased in 87% of 30 patients with cirrhosis, in 16% of 32 with steatofibrosis but in none of 11 with steatosis. There was a significant correlation with histologic hepatocellular necroinflammation (r = 0.42, p less than 0.01), but not with hepatic fibrosis. sPIIP was increased in 33% of 30 patients with IHC, whether or not they had cirrhosis or fibrosis, and whatever the level of iron overload or the extent of the hepatic deterioration. IHC patients with increased levels of sPIIIP had a higher prevalence of superimposed hepatic damage than did those with normal procollagen levels (p less than 0.05). Our findings, therefore, weaken the diagnostic value of sPIIIP as an index of connective tissue deposition in the liver, and suggest that, at least in alcohol-related liver disease and IHC, hepatocellular necroinflammation influences the results. |
| Databáze: | OpenAIRE |
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