Ultrasonic sculpting of virtual optical waveguides in tissue
| Autor: | Julien Bloch, Mohammad-Reza Alam, Ninh Do, Matteo Giuseppe Scopelliti, Vikaas S. Sohal, Jillian Iafrati, Maysamreza Chamanzar, Minyoung Huh, Michel M. Maharbiz, Dongjin Seo |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Optical fiber Materials science Flexibility (anatomy) Science General Physics and Astronomy 02 engineering and technology Models Biological General Biochemistry Genetics and Molecular Biology Article law.invention 03 medical and health sciences Mice Optics Imaging Three-Dimensional law medicine Local pressure Animals Ultrasonics Computer Simulation lcsh:Science Ultrasonography Multidisciplinary Scattering business.industry Optical Imaging Brain General Chemistry Acoustic wave 021001 nanoscience & nanotechnology Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Sound Trajectory Ultrasonic sensor lcsh:Q 0210 nano-technology business Refractive index Photic Stimulation |
| Zdroj: | Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Optical imaging and stimulation are widely used to study biological events. However, scattering processes limit the depth to which externally focused light can penetrate tissue. Optical fibers and waveguides are commonly inserted into tissue when delivering light deeper than a few millimeters. This approach, however, introduces complications arising from tissue damage. In addition, it makes it difficult to steer light. Here, we demonstrate that ultrasound can be used to define and steer the trajectory of light within scattering media by exploiting local pressure differences created by acoustic waves that result in refractive index contrasts. We show that virtual light pipes can be created deep into the tissue (>18 scattering mean free paths). We demonstrate the application of this technology in confining light through mouse brain tissue. This technology is likely extendable to form arbitrary light patterns within tissue, extending both the reach and the flexibility of light-based methods. Optical imaging of tissue is a powerful technique but delivering light deep into scattering tissue is not possible without using invasive methods. Here, the authors demonstrate that patterned ultrasound can define and control the trajectory of light in tissue using pressure-induced index contrasts. |
| Databáze: | OpenAIRE |
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