Acamprosate attenuates the handling induced convulsions during alcohol withdrawal in Swiss Webster mice
| Autor: | Dennis J. Morrell, Ben Lewis, Susan Barron, John M. Littleton, Ali Krazem, Justin M. Farook |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.drug_class Taurine Acamprosate Antidotes Experimental and Cognitive Psychology Alcohol Pharmacology Handling Psychological Article Alcohol Withdrawal Seizures Behavioral Neuroscience chemistry.chemical_compound Mice medicine Animals Drug Interactions Fomepizole Alcohol dehydrogenase Benzodiazepine Analysis of Variance Diazepam biology Behavior Animal Dose-Response Relationship Drug business.industry Disease Models Animal chemistry Alcohol Deterrents Alcohols biology.protein Pyrazoles Anticonvulsants business medicine.drug |
| Popis: | In the present study, we examined the effects of acamprosate for its ability to reduce handling induced convulsions (HICs) during alcohol withdrawal. Diazepam was used as a positive control. Swiss Webster male mice received three daily IP injections of alcohol (2.5 g/kg) or alcohol (2.5 g/kg) + methylpyrazole (4-MP) (9 mg/kg). (4-MP, being an alcohol dehydrogenase inhibitor slows down the breakdown of alcohol. 4-MP in combination with alcohol exhibits a dramatic increase in blood alcohol level compared to alcohol alone). Ten hours following the last alcohol injection, the mice were picked up by the tail and examined for their seizure susceptibility (HICs). Diazepam, a benzodiazepine known to reduce seizures during alcohol withdrawal, significantly reduced these HICs at doses of 0.25, 0.5 and 1mg/kg (p’s < 0.001). Acamprosate, an anti-relapse compound used clinically in newly abstinent alcoholics, also reduced these HICs at doses of 100, 200 and 300mg/kg (p’s < 0.05). This study supports the use of acamprosate during periods of alcohol withdrawal as well as during abstinence. |
| Databáze: | OpenAIRE |
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