Reproduction of post-weaning multi-systemic wasting syndrome in an animal disease model as a tool for vaccine testing under controlled conditions
| Autor: | Veronica Casement, Paula Lagan, Julie McClintock, Catherine Elisabeth Charreyre, John McKillen, Karen McKay, I. McNair, Gordon Allan |
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| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
Circovirus Porcine parvovirus food.ingredient Swine viruses animal diseases Erysipelothrix rhusiopathiae Serology Parvoviridae Infections 03 medical and health sciences Erysipelothrix Infections Porcine Postweaning Multisystemic Wasting Syndrome fluids and secretions Erysipelothrix food Medicine Animals Swine Diseases General Veterinary biology business.industry virus diseases Viral Vaccines Parvovirus Porcine biology.organism_classification Virology Bacterial vaccine Porcine circovirus Disease Models Animal 030104 developmental biology Immunology Bacterial Vaccines Colostrum business |
| Zdroj: | Research in veterinary science. 105 |
| ISSN: | 1532-2661 |
| Popis: | Snatch farrowed, colostrum deprived piglets were inoculated with different combinations of porcine circovirus 2, porcine parvovirus and Erysipelothrix rhusiopathiae candidate vaccines. 10 piglets were mock-vaccinated. Following virus challenge with a combined porcine circovirus 2/porcine parvovirus inoculum, all animals were monitored and samples taken for serology, immunohistochemistry and qPCR. At 24 dpc all non-vaccinated animals remaining were exhibiting signs of post-weaning multi-systemic wasting syndrome which was confirmed by laboratory analysis. Details of the study, analysis of samples and performance of the candidate vaccines are described. |
| Databáze: | OpenAIRE |
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