Expression pattern of osteogenic protein-1 (bone morphogenetic protein-7) in human and mouse development
| Autor: | Kuber T. Sampath, Slobodan Vukicevic, Frank P. Luyten, M N Helder, V. Latin, Hermann Oppermann, Engin Ozkaynak |
|---|---|
| Přispěvatelé: | Orale Celbiologie (OUD, ACTA) |
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Histology Limb Buds Transcription Genetic Bone Morphogenetic Protein 7 Bone morphogenetic protein 8A Gene Expression Gestational Age Biology Kidney Bone morphogenetic protein Bone morphogenetic protein 2 Bone and Bones Embryonic and Fetal Development Mice Fetus Transforming Growth Factor beta Internal medicine medicine Animals Humans RNA Messenger In Situ Hybridization Myocardium Proteins Bone morphogenetic protein 10 Heart Embryo Mammalian Cell biology Bone morphogenetic protein 7 Bone morphogenetic protein 6 Blastocyst Bone morphogenetic protein 5 Endocrinology Organ Specificity GDF6 Protein Biosynthesis Bone Morphogenetic Proteins Female Anatomy |
| Zdroj: | Helder, M N, Ozkaynak, E, Sampath, U T, Luyten, F P, Opperman, H & Vukicevic, S 1995, ' Expression pattern of osteogenic protein-1 (bone morphogenetic protein-7) in human and mouse development. ', The Journal of Histochemistry and Cytochemistry, vol. 43, pp. 1035-1044 . https://doi.org/10.1177/43.10.7560881 The Journal of Histochemistry and Cytochemistry, 43, 1035-1044. Histochemical Society Inc. |
| ISSN: | 1551-5044 0022-1554 |
| DOI: | 10.1177/43.10.7560881 |
| Popis: | Osteogenic protein-1 (OP-1; BMP-7) is a member of the bone morphogenetic protein subfamily. Because members of the TGF-beta superfamily have a role in tissue development, the distribution of OP-1 expression in developing human embryos (5-8 gestational weeks) and fetuses (8-14 gestational weeks) and mouse (9.5-17.5 gestational days) fetuses was examined. Northern hybridization with specific OP-1 probes revealed two mRNA species of 4 and 2.2 KB. Highest levels of OP-1 mRNA were found in human fetal kidney and heart between 12-14 weeks of gestation. By in situ hybridization, the OP-1 transcripts were found in various tissues, i.e., the ectodermal epithelium of the mouse fore- and hindlimbs, heart, teeth, intestinal epithelium, perichondrium, hypertrophic chondrocytes, and periosteum/osteoblast layer of developing human bones. In kidneys, transcripts were first detected in the epithelium of the branching uretheric buds, whereas at later stages glomeruli were the major site of OP-1 mRNA accumulation. These data suggest that, although OP-1 has been isolated from bone matrix, it may have additional regulatory roles in the morphogenesis and/or function of the kidney, limb bud, tooth, heart, and intestine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|