International warfarin genotype-guided dosing algorithms in the Turkish population and their preventive effects on major and life-threatening hemorrhagic events
| Autor: | Mehmet Karaca, Sefayet Karaca, Tomris Cesuroglu, Mehmet Bozkurt, Renato Polimanti, Nujen Colak Bozkurt, Erdal Eskioglu |
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| Přispěvatelé: | Sağlık Bilimleri Fakültesi, Polimanti, Renato -- 0000-0003-0745-6046, Bozkurt, Mehmet -- 0000-0002-8325-5249, Science Communication, Sociale Geneeskunde, RS: CAPHRI - R4 - Health Inequities and Societal Participation |
| Rok vydání: | 2015 |
| Předmět: |
International Normalized Ratio/methods
Male Drug Response Turkish population Genotype Turkey Turkish Validation Study Hemorrhagic Disorders Thromboembolism/drug therapy Warfarin/administration & dosage Therapeutic index SDG 3 - Good Health and Well-being Thromboembolism Ethnicity Genetics medicine Humans heterocyclic compounds Drug Dosage Calculations Hemorrhagic Disorders/genetics International Normalized Ratio cardiovascular diseases Dosing Pharmacogenetics/methods Aged Anticoagulants/administration & dosage Pharmacology business.industry Warfarin dose Warfarin Anticoagulants Middle Aged language.human_language Pharmacogenetics Pharmacogenetic Algorithms language Molecular Medicine Female business Algorithm Algorithms medicine.drug |
| Zdroj: | Pharmacogenomics, 16(10), 1109-18. Future Medicine Ltd. Pharmacogenomics, 16(10), 1109-1118. Future Medicine Ltd. Karaca, S, Bozkurt, N C, Cesuroglu, T, Karaca, M, Bozkurt, M, Eskioglu, E & Polimanti, R 2015, ' International warfarin genotype-guided dosing algorithms in the Turkish population and their preventive effects on major and life-threatening hemorrhagic events ', Pharmacogenomics, vol. 16, no. 10, pp. 1109-18 . https://doi.org/10.2217/pgs.15.58 |
| ISSN: | 1744-8042 1462-2416 |
| Popis: | WOS: 000361140600008 PubMed: 26216670 To determine the accuracy of international warfarin pharmacogenetic algorithms developed on large multiethnic cohorts (comprising more than 1000 subjects) to predict therapeutic warfarin doses in Turkish patients. Materials & methods: We investigated two Turkish warfarin-treated cohorts: patients with no history of hemorrhagic or thromboembolic event and patients with major and life-threatening hemorrhagic events. Results: International pharmacogenetic algorithms showed good performances in predicting the therapeutic dose of patients with no history of bleedings, but they did not significantly detect the incorrect warfarin dose of patients with major and life-threatening hemorrhagic events. Conclusion: Although genetic information can predict the therapeutic warfarin dose, the accuracy of the international pharmacogenetic algorithms is not sufficient to be used for warfarin screening in Turkish patients. Turkish Society of Internal Medicine This research was funded by the Research Projects Fund of Turkish Society of Internal Medicine. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. |
| Databáze: | OpenAIRE |
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