Comparable effect of conventional ventilation versus early high-frequency oscillation on serum CC16 and IL-6 levels in preterm neonates
| Autor: | Eleni Agakidou, Elisavet Diamanti, Kosmas Sarafidis, Theodora Stathopoulou, Anna Taparkou, Vassiliki Soubasi, V Drossou |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Ventilator-Induced Lung Injury medicine.medical_treatment High-Frequency Ventilation High frequency oscillation Internal medicine medicine Humans Uteroglobin Interleukin 6 Respiratory Distress Syndrome Newborn biology Interleukin-6 business.industry High-frequency ventilation Infant Newborn Obstetrics and Gynecology Infant newborn Anesthesia Pediatrics Perinatology and Child Health biology.protein Cardiology RESPIRATORY DISTRESS SYNDROME NEWBORN business Bronchoalveolar Lavage Fluid Biomarkers Infant Premature Conventional ventilation |
| Zdroj: | Journal of Perinatology. 31:104-111 |
| ISSN: | 1476-5543 0743-8346 |
| DOI: | 10.1038/jp.2010.78 |
| Popis: | Clara cell 16 kD protein (CC16) and interleukin (IL)-6 have been used as peripheral blood biomarkers of alveolar leakage and inflammation, respectively. Thus, their measurement in the bloodstream could be used to assess ventilator-induced lung injury. The objective of this study was to evaluate the effect of optimized synchronized intermittent mandatory ventilation (SIMV) and high-frequency oscillatory ventilation (HFOV) on circulating CC16 and IL-6 levels when used as the initial ventilation modes in preterm neonates.Single center, prospective, randomized clinical study in preterm neonates (gestational age 30 weeks) requiring mechanical ventilation within the first 2 h of life. Serum CC16 and IL-6 were measured on establishment of the assigned ventilation mode after admission, at days 3 and 14 of life as well as at 36 weeks postmenstrual age. Demographic-perinatal data and clinical parameters were also recorded.Of the 30 neonates studied, 24 (gestational age 27.1±1.7 weeks, birth weight 942±214 g) were finally analyzed, equally assigned into the SIMV and HFOV groups. Both groups had comparable demographic-perinatal characteristics and clinical parameters. Serum CC16 and IL-6 altered significantly over time (repeated-measures analysis of variance, both P0.001). However, changes were not affected by the ventilation mode. Post hoc analysis showed a significant decrease in CC16 and IL-6 from birth up to 36 weeks postmenstrual age in both groups.In preterm neonates, SIMV and HFOV are associated with comparable circulating CC16 and IL-6 levels. These findings suggest a similar alveolar leakage and systemic inflammation with any of the ventilation modes evaluated when their usage is optimized. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|