Analysis of associations between genetic markers of erythrocytes of ав0, Rh, mn, P, kell blood group systems and arterial hypertension at the Altai Republic population
| Autor: | E G Onishchenko, S N Filimonov, F A Luzina, T. A. Mulerova, M U Ogargov |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2012 |
| Předmět: |
education.field_of_study
lcsh:Diseases of the circulatory (Cardiovascular) system hypertension business.industry Population Ethnic group kell Ethnic origin Disease Kell antigen system blood groups mn mn) antigens system lcsh:RC666-701 Relative risk ABO blood group system Genetic predisposition Medicine rh erythrocytic (ab0 education business rh-hr genetic predisposition Demography |
| Zdroj: | Системные гипертензии, Vol 9, Iss 4, Pp 65-68 (2012) |
| ISSN: | 2542-2189 |
| Popis: | Objectives: the aim is to estimate the share of people with AH among the Tubalars and nonindigenous inhabitants of the Altai Republic taking into account a sex, an ethnic origin and to analyze genetic predisposition to the diseases of АВ0, Rh, MN, P, Kell blood group systems. Materials and methods. There was clinico-epidemiologic survey of the Altai Republic population (sample of 935 people, 663 people of them are Tubalars, 272 people are nonindigenous) aged from 18 till 88 years. Arterial hypertension was diagnosed according to criteria of WHO/MOAG of 1999. The study of genetic markers was carried out according to the standard methodology, blood group systems were defined: ABO, «full» Rhesus factor, MN, P, Kell. The sample size of different systems made from 301 to 425 people. The force of association between studied markers and the disease was judged according to the criterion of relative risk. Results. 38,6% Tubalars and 40,8% nonindigenous population were diagnosed with arterial hypertension. The share of people with Rh(+) blood group is larger among Tubalars (94,6%) in comparison with nonindigenous representatives (87,4%; p |
| Databáze: | OpenAIRE |
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