Cardiovascular risk assessment and association with novel biomarkers in patients with Type 2 diabetes mellitus
| Autor: | Marina de Psf Nunes, Elizabeth De Francesco Daher, Gdayllon Cavalcante Meneses, Ricardo Pereira Silva, Danielli Oliveira da Costa Lino, Geraldo Bezerra da Silva Junior, Ane Km Néri, Alice Mc Martins, Renan Lima Alencar, Mariane S Rodrigues, Igor P Saraiva |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Urinary system Clinical Biochemistry 030232 urology & nephrology Type 2 diabetes 030204 cardiovascular system & hematology Risk Assessment 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Drug Discovery medicine Humans In patient Prospective Studies Endothelial dysfunction Aged Subclinical infection business.industry Biochemistry (medical) Type 2 Diabetes Mellitus Middle Aged medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 2 Cardiovascular Diseases Heart Disease Risk Factors Female Risk assessment business Biomarkers |
| Zdroj: | Biomarkers in Medicine. 15:561-576 |
| ISSN: | 1752-0371 1752-0363 |
| DOI: | 10.2217/bmm-2020-0611 |
| Popis: | Aim: To investigate the association between cardiovascular risk and biomarkers in patients with Type 2 diabetes (T2DM). Methods: Cross-sectional study, with evaluation of traditional and new biomarkers (serum FGF-23, Syndecan-1 [Sdc-1] and vascular cell adhesion molecule-1 [VCAM-1] and urinary VEGF and kidney injury molecule-1 [KIM-1]) and risk scores (Framingham-FRS and UK Prospective Diabetes Study [UKPDS]). Results: 128 diabetics were included, with predominance of high risk by FRS and low risk by UKPDS. There was an independent association of VCAM-1 and VEGF with higher risk by FRS-lipids and UKPDS. Conclusion: There was an independent association of VCAM-1 and VEGF with higher cardiovascular risk, showing a subclinical endothelial dysfunction in T2DM. The inclusion of novel biomarkers to risk scores may increase accuracy when assessing cardiovascular risk of diabetic individuals. |
| Databáze: | OpenAIRE |
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